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Literature summary extracted from

  • Szalewicz, A.; Strzelczyk, B.; Sopel, M.; Kubicz, A.
    The 35 kDa acid metallophosphatase of the frog Rana esculenta liver: studies on its cellular localization and protein phosphatase activity (2003), Acta Biochim. Pol., 50, 555-566.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.2 molybdate strong competitive inhibitor, competitive with 4-nitrophenyl phosphate Pelophylax lessonae
3.1.3.2 additional information the enzyme is not inhibited by okadaic acid and F- Pelophylax lessonae
3.1.3.2 phosphate competitive with 4-nitrophenyl phosphate, competitive with 4-nitrophenyl phosphate Pelophylax lessonae
3.1.3.2 phosphotyrosine competitive with 4-nitrophenyl phosphate Pelophylax lessonae
3.1.3.2 tungstate strong competitive inhibitor, competitive with 4-nitrophenyl phosphate Pelophylax lessonae
3.1.3.2 vanadate strong competitive inhibitor, competitive with 4-nitrophenyl phosphate Pelophylax lessonae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.2 0.00755
-
 hirudin 53-65 C-terminal fragment pH 5.0, 37°C Pelophylax lessonae
3.1.3.2 0.273
-
 phosvitin per number of phosphoserine residues, pH 5.0, 37°C Pelophylax lessonae
3.1.3.2 1.38
-
 phosphotyrosine pH 5.0, 37°C Pelophylax lessonae
3.1.3.2 1.39
-
 4-nitrophenyl phosphate pH 5.0, 37°C Pelophylax lessonae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.2 cytoplasm
-
 Pelophylax lessonae 5737
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.2 Pelophylax lessonae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.2 hepatocyte enzyme does not appear in other cells of liver tissue Pelophylax lessonae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Pelophylax lessonae 4-nitrophenol + phosphate
-
 ?
3.1.3.2 hirudin 53-65 C-terminal fragment + H2O containing phosphotyrosine63 Pelophylax lessonae ?
-
 ?
3.1.3.2 phosphotyrosine + H2O
-
 Pelophylax lessonae phosphate + tyrosine
-
 ?
3.1.3.2 phosvitin + H2O protein containing phosphoserine, poor substrate Pelophylax lessonae ?
-
 ?
3.1.3.2 rabbit 32P-phosphorylase a + H2O protein containing phosphoserine, poor substrate Pelophylax lessonae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.2 LMW AcPase
-
 Pelophylax lessonae
3.1.3.2 low molecular mass acid phosphatase
-
 Pelophylax lessonae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.2 0.0000036
-
 tungstate pH 5.0, 37°C Pelophylax lessonae
3.1.3.2 0.00055
-
 molybdate pH 5.0, 37°C Pelophylax lessonae
3.1.3.2 0.00955
-
 vanadate pH 5.0, 37°C Pelophylax lessonae
3.1.3.2 0.213
-
 phosphate pH 5.0, 37°C Pelophylax lessonae