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Literature summary extracted from
- Structure, catalytic activity and evolutionary relationships of 1-aminocyclopropane-1-carboxylate synthase, the key enzyme of ethylene synthesis in higher plants (2002), Acta Biochim. Pol., 49, 757-774.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.4.1.14 | expression in Escherichia coli and Saccharomyces cerevisiae | Cucurbita pepo |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.4.1.14 | in complex with pyridoxal 5'-phosphate and aminoethoxyvinylglycine | Solanum lycopersicum |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.4.1.14 | R286A | almost complete loss of activity | Solanum lycopersicum |
| 4.4.1.14 | R286I | almost complete loss of activity | Solanum lycopersicum |
| 4.4.1.14 | R286L | low affinity for pyridoxal 5' phosphate and S-adenosylmethionine | Solanum lycopersicum |
| 4.4.1.14 | R286T | almost complete loss of activity | Solanum lycopersicum |
| 4.4.1.14 | R286V | almost complete loss of activity | Solanum lycopersicum |
| 4.4.1.14 | R407L | 20fold increase in Km for s-adenosyl-l-methionine | Malus domestica |
| 4.4.1.14 | Y233F | 24fold increase in Km for s-adenosyl-L-methionine | Malus domestica |
| 4.4.1.14 | Y85A | inactive ACC synthase | Malus domestica |
| 4.4.1.14 | Y92F | partially active ACC synthase | Solanum lycopersicum |
| 4.4.1.14 | Y92H | no activity | Solanum lycopersicum |
| 4.4.1.14 | Y92L | no activity | Solanum lycopersicum |
| 4.4.1.14 | Y92W | partially active ACC synthase | Solanum lycopersicum |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.14 | aminoethoxyvinylglycine | - |
Solanum lycopersicum |  |
| 4.4.1.14 | L-vinylglyine | - |
Solanum lycopersicum | |
| 4.4.1.14 | methoxyethoxyvinylglycine | - |
Solanum lycopersicum | |
| 4.4.1.14 | rhizobitoxine | - |
Solanum lycopersicum | |
| 4.4.1.14 | S-(3-deazaadenosyl)homocysteine | - |
Solanum lycopersicum | |
| 4.4.1.14 | S-adenosyl-L-homocysteine | - |
Solanum lycopersicum | |
| 4.4.1.14 | S-adenosyl-L-methionine | mechanism-based inactivation | Solanum lycopersicum | |
| 4.4.1.14 | S-isobutyl-1-deazaadenosine | - |
Solanum lycopersicum | |
| 4.4.1.14 | S-isobutyl-3-deazaadenosine | - |
Solanum lycopersicum | |
| 4.4.1.14 | S-isobutyl-7-deazaadenosine | - |
Solanum lycopersicum | |
| 4.4.1.14 | S-isobutyladenosine | - |
Solanum lycopersicum | |
| 4.4.1.14 | sinefungin | naturally occuring antifungal antibiotic isolated from Streptomyces griseus | Solanum lycopersicum | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.4.1.14 | cytoplasm | - |
Solanum lycopersicum | 5737 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.14 | 50200 | - |
x * 50200, isoenzyme ACS2 | Solanum tuberosum |
| 4.4.1.14 | 51000 | - |
x * 51000, isoenzymes ACS4 and ACS5 | Lupinus albus |
| 4.4.1.14 | 52900 | - |
x * 52900, iosenzymes ACS1A and ACS1B | Solanum tuberosum |
| 4.4.1.14 | 53100 | - |
x * 53100, iosenzyme ACS1 | Oryza sativa |
| 4.4.1.14 | 53300 | - |
x * 53300, iosenzyme ACS2 | Citrus sinensis |
| 4.4.1.14 | 53800 | - |
x * 53800, iosenzymes ACS4 and ACS5 | Arabidopsis thaliana |
| 4.4.1.14 | 54100 | - |
x * 54100, iosenzyme ACS1 | Citrus sinensis |
| 4.4.1.14 | 54100 | - |
x * 54100, iosenzyme ACS1 | Pelargonium x hortorum |
| 4.4.1.14 | 54600 | - |
x * 54600, iosenzyme ACS1 | Arabidopsis thaliana |
| 4.4.1.14 | 54600 | - |
x * 54600, iosenzyme ACS1 | Vigna radiata |
| 4.4.1.14 | 55000 | - |
x * 55000, iosenzyme ACS2 | Brassica oleracea |
| 4.4.1.14 | 55000 | - |
x * 55000, iosenzymes ACS1 and ACS3 | Lupinus albus |
| 4.4.1.14 | 55600 | - |
x * 55600, iosenzyme ACS2 | Arabidopsis thaliana |
| 4.4.1.14 | 55800 | - |
x * 55800, iosenzyme ACS | Cucurbita maxima |
| 4.4.1.14 | 55800 | - |
x * 55800, iosenzyme ACS1A | Cucurbita pepo |
| 4.4.1.14 | 55900 | - |
x * 55900, iosenzyme ACS1B | Cucurbita pepo |
| 4.4.1.14 | 56000 | - |
x * 56000, iosenzyme ACS1 | Cucumis melo |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.14 | S-adenosyl-L-methionine | Solanum tuberosum | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Arabidopsis thaliana | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Lupinus albus | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Vigna radiata | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Solanum lycopersicum | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Brassica oleracea | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Cucurbita pepo | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Oryza sativa | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Cucurbita maxima | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Citrus sinensis | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Cucumis melo | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Malus domestica | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | Pelargonium x hortorum | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.14 | Arabidopsis thaliana | - |
- |
- |
| 4.4.1.14 | Brassica oleracea | - |
- |
- |
| 4.4.1.14 | Citrus sinensis | - |
- |
- |
| 4.4.1.14 | Cucumis melo | - |
- |
- |
| 4.4.1.14 | Cucurbita maxima | - |
- |
- |
| 4.4.1.14 | Cucurbita pepo | - |
- |
- |
| 4.4.1.14 | Lupinus albus | - |
- |
- |
| 4.4.1.14 | Malus domestica | - |
apple | - |
| 4.4.1.14 | Oryza sativa | - |
- |
- |
| 4.4.1.14 | Pelargonium x hortorum | - |
- |
- |
| 4.4.1.14 | Solanum lycopersicum | - |
- |
- |
| 4.4.1.14 | Solanum tuberosum | - |
- |
- |
| 4.4.1.14 | Vigna radiata | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Solanum tuberosum | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Arabidopsis thaliana | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Lupinus albus | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Vigna radiata | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Solanum lycopersicum | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Brassica oleracea | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Cucurbita pepo | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Oryza sativa | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Cucurbita maxima | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Citrus sinensis | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Cucumis melo | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Malus domestica | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| 4.4.1.14 | S-adenosyl-L-methionine | - |
Pelargonium x hortorum | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.4.1.14 | ? | x * 50200, isoenzyme ACS2 | Solanum tuberosum |
| 4.4.1.14 | ? | x * 51000, isoenzymes ACS4 and ACS5 | Lupinus albus |
| 4.4.1.14 | ? | x * 52900, iosenzymes ACS1A and ACS1B | Solanum tuberosum |
| 4.4.1.14 | ? | x * 53100, iosenzyme ACS1 | Oryza sativa |
| 4.4.1.14 | ? | x * 53100-54800 | Solanum lycopersicum |
| 4.4.1.14 | ? | x * 53300, iosenzyme ACS2 | Citrus sinensis |
| 4.4.1.14 | ? | x * 53800, iosenzymes ACS4 and ACS5 | Arabidopsis thaliana |
| 4.4.1.14 | ? | x * 54100, iosenzyme ACS1 | Citrus sinensis |
| 4.4.1.14 | ? | x * 54100, iosenzyme ACS1 | Pelargonium x hortorum |
| 4.4.1.14 | ? | x * 54600, iosenzyme ACS1 | Arabidopsis thaliana |
| 4.4.1.14 | ? | x * 54600, iosenzyme ACS1 | Vigna radiata |
| 4.4.1.14 | ? | x * 55000, iosenzyme ACS2 | Brassica oleracea |
| 4.4.1.14 | ? | x * 55000, iosenzymes ACS1 and ACS3 | Lupinus albus |
| 4.4.1.14 | ? | x * 55600, iosenzyme ACS2 | Arabidopsis thaliana |
| 4.4.1.14 | ? | x * 55800, iosenzyme ACS | Cucurbita maxima |
| 4.4.1.14 | ? | x * 55800, iosenzyme ACS1A | Cucurbita pepo |
| 4.4.1.14 | ? | x * 55900, iosenzyme ACS1B | Cucurbita pepo |
| 4.4.1.14 | ? | x * 56000, iosenzyme ACS1 | Cucumis melo |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.4.1.14 | ACC synthase | - |
Solanum lycopersicum |
| 4.4.1.14 | ACC synthase | - |
Malus domestica |
| 4.4.1.14 | ACS | - |
Solanum tuberosum |
| 4.4.1.14 | ACS | - |
Arabidopsis thaliana |
| 4.4.1.14 | ACS | - |
Lupinus albus |
| 4.4.1.14 | ACS | - |
Vigna radiata |
| 4.4.1.14 | ACS | - |
Solanum lycopersicum |
| 4.4.1.14 | ACS | - |
Brassica oleracea |
| 4.4.1.14 | ACS | - |
Cucurbita pepo |
| 4.4.1.14 | ACS | - |
Oryza sativa |
| 4.4.1.14 | ACS | - |
Cucurbita maxima |
| 4.4.1.14 | ACS | - |
Citrus sinensis |
| 4.4.1.14 | ACS | - |
Cucumis melo |
| 4.4.1.14 | ACS | - |
Malus domestica |
| 4.4.1.14 | ACS | - |
Pelargonium x hortorum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Solanum tuberosum | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Arabidopsis thaliana | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Lupinus albus | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Vigna radiata | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Solanum lycopersicum | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Brassica oleracea | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Cucurbita pepo | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Oryza sativa | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Cucurbita maxima | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Citrus sinensis | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Cucumis melo | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Malus domestica | |
| 4.4.1.14 | pyridoxal 5'-phosphate | - |
Pelargonium x hortorum | |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 4.4.1.14 | Cucurbita maxima | isoenzyme ACS | - |
5 |
| 4.4.1.14 | Solanum tuberosum | isoenzyme ACS2 | - |
5.74 |
| 4.4.1.14 | Brassica oleracea | isoenzyme ACS2 | - |
5.9 |
| 4.4.1.14 | Vigna radiata | isoenzyme ACS1 | - |
6 |
| 4.4.1.14 | Pelargonium x hortorum | isoenzyme ACS1 | - |
6.4 |
| 4.4.1.14 | Cucumis melo | isoenzyme ACS1 | - |
6.41 |
| 4.4.1.14 | Lupinus albus | isoenzyme ACS5 | - |
6.44 |
| 4.4.1.14 | Lupinus albus | isoenzyme ACS4 | - |
6.58 |
| 4.4.1.14 | Citrus sinensis | isoenzyme ACS1 | - |
6.63 |
| 4.4.1.14 | Citrus sinensis | isoenzyme ACS2 | - |
6.72 |
| 4.4.1.14 | Lupinus albus | isoenzyme ACS1 | - |
7.06 |
| 4.4.1.14 | Arabidopsis thaliana | isoenzymes ACS1 and ACS2 | 7.4 | 7.3 |
| 4.4.1.14 | Arabidopsis thaliana | isoenzyme ACS5 | - |
7.5 |
| 4.4.1.14 | Lupinus albus | isoenzyme ACS3 | - |
7.61 |
| 4.4.1.14 | Solanum tuberosum | isoenzyme ACS1A | - |
7.86 |
| 4.4.1.14 | Oryza sativa | isoenzyme ACS1 | - |
8.2 |
| 4.4.1.14 | Arabidopsis thaliana | isoenzyme ACS4 | - |
8.2 |
| 4.4.1.14 | Solanum tuberosum | isoenzyme ACS1B | - |
8.23 |
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