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Literature summary extracted from

  • Hofer, A.; Steverding, D.; Chabes, A.; Brun, R.; Thelander, L.
    Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness (2001), Proc. Natl. Acad. Sci. USA, 98, 6412-6416.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.3.4.2 medicine the enzyme is an target for treatment of African sleeping sickness because the trypanosomes, unlike mammalian cells, cannot compensate for the inhibition of CTP synthetase by the salvage of cytidine. The CTP synthetase inhibitors 6-diazo-5-oxo-L-norleucine and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid reduce the parasite CTP level even further and inhibit trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.2 6-diazo-5-oxo-L-norleucine reduces the parasite CTP level even further and inhibits trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice Trypanosoma brucei
6.3.4.2 alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid reduces the parasite CTP level even further and inhibits trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.2 Trypanosoma brucei
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.2 ATP + UTP + NH4+
-
 Trypanosoma brucei ADP + phosphate + CTP
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