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Literature summary extracted from

  • Abiko, Y.
    Pantothenic acid and coenzyme A: phosphopantothenoylcysteine synthetase from rat liver (pantothenate 4¦-phosphate: L-cysteine ligase, EC 6.3.2.5) (1976), Methods Enzymol., 18A, 350-354.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.5 EDTA
-
Rattus norvegicus
6.3.2.5 KCl
-
Rattus norvegicus
6.3.2.5 NaCl
-
Rattus norvegicus
6.3.2.5 phosphate
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.5 0.071 0.083 4'-phosphopantothenate 37°C, pH 7.5 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.5 Mg2+ required Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.5 37000
-
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.5 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.5
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.5 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.2.5 additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.5 ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide
-
Rattus norvegicus ?
-
?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + 2-methylcysteine
-
Rattus norvegicus N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate
-
?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine
-
Rattus norvegicus phosphopantetheine + ADP + phosphate
-
?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + L-Cys
-
Rattus norvegicus (R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.5 7.5
-
-
Rattus norvegicus