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Literature summary extracted from

  • Laub, M.; Jennissen, H.P.
    Synthesis and decay of calmodulin-ubiquitin conjugates in cell-free extracts of various rabbit tissues (1997), Biochim. Biophys. Acta, 1357, 173-191.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.B11 Ca2+ the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.B11 n ATP + calmodulin + n ubiquitin Oryctolagus cuniculus the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B11 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.B11 brain high activity Oryctolagus cuniculus
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2.3.2.B11 erythrocyte high activity Oryctolagus cuniculus
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2.3.2.B11 red muscle skeletal Oryctolagus cuniculus
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2.3.2.B11 reticulocyte high activity Oryctolagus cuniculus
-
2.3.2.B11 spleen high activity Oryctolagus cuniculus
-
2.3.2.B11 testis high activity Oryctolagus cuniculus
-
2.3.2.B11 white muscle skeletal Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B11 n ATP + calmodulin + n ubiquitin the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold Oryctolagus cuniculus ?
-
 ?
2.3.2.B11 [RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine
-
 Oryctolagus cuniculus [RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.B11 More two components of the ligase can be identified: uCaM Syn-F1 and uCaM Syn-F2, the first of which binds to ubiquitin and the second which binds to calmodulin Oryctolagus cuniculus