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Literature summary extracted from

  • Mihara, H.; Esaki, N.
    Selenocysteine lyase from mouse liver (2002), Methods Enzymol., 347, 198-203.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.16 expressed in Escherichia coli BL21(DE3) Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.16 hydroxylamine almost completely reversible by dialysis against pyridoxal 5'-phosphate Mus musculus
4.4.1.16 NaBH4 irreversible Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.16 8.6
-
L-cysteine sulfinate pH 9.0, 37°C Mus musculus
4.4.1.16 9.9
-
L-selenocysteine pH 9.0, 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.16 cytoplasm
-
Mus musculus 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.4.1.16 47000
-
SDS-PAGE Mus musculus
4.4.1.16 47200
-
calculated from amino acid sequence Mus musculus
4.4.1.16 105000
-
gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.16 L-selenocysteine + reduced acceptor Mus musculus
-
selenide + L-alanine + acceptor
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.16 Mus musculus Q9JLI6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.16 overexpressed protein Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.16 brain
-
Mus musculus
-
4.4.1.16 heart
-
Mus musculus
-
4.4.1.16 kidney
-
Mus musculus
-
4.4.1.16 liver
-
Mus musculus
-
4.4.1.16 lung
-
Mus musculus
-
4.4.1.16 spleen
-
Mus musculus
-
4.4.1.16 stomach
-
Mus musculus
-
4.4.1.16 testis
-
Mus musculus
-

Storage Stability

EC Number Storage Stability Organism
4.4.1.16 -80°C, purified enzyme, stable for several weeks Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.16 L-cysteine sulfinic acid + reduced acceptor
-
Mus musculus SO2 + L-alanine + acceptor
-
?
4.4.1.16 L-selenocysteine + reduced acceptor
-
Mus musculus selenide + L-alanine + acceptor
-
?
4.4.1.16 additional information traces of activity with L-cysteine Mus musculus ?
-
?

Subunits

EC Number Subunits Comment Organism
4.4.1.16 dimer 2 * 47000, SDS-PAGE Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.4.1.16 0.35
-
L-cysteine sulfinate pH 9.0, 37°C Mus musculus
4.4.1.16 46
-
L-selenocysteine pH 9.0, 37°C Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.16 pyridoxal 5'-phosphate required Mus musculus