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Literature summary extracted from

  • Warner, H.R.; Persson, M.L.; Bensen, R.J.; Mosbaugh, D.W.; Linn, S.
    Selective inhibition by harmane of apurinic/apyrimidinic endonuclease activity of phage T4-induced UV endonuclease (1981), Nucleic Acids Res., 9, 6083-6092.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.99.18 Harmane i.e. 1-methyl-9H-pyrido-[3,4-b]indole, inhibits Escherichia coli endonuclease III and its associated dihydroxythymidine-DNA glycosylase activity, 50% inhibition at 0.4 mM, 80% inhibition at 1 mM Escherichia coli
4.2.99.18 Harmane i.e. 1-methyl-9H-pyrido-[3,4-b]indole, only slight inhibition of AP endocunlease I and II Homo sapiens
4.2.99.18 Harmane i.e. 1-methyl-9H-pyrido-[3,4-b]indole, inhibits Escherichia coli endonuclease III and its associated dihydroxythymidine-DNA glycosylase activity, 50% inhibition at 0.4 mM, 80% inhibition at 1 mM Tequatrovirus T4

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.99.18 DNA Escherichia coli
-
 fragments of DNA
-
 ?
4.2.99.18 DNA Homo sapiens
-
 fragments of DNA
-
 ?
4.2.99.18 DNA Tequatrovirus T4
-
 fragments of DNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.99.18 Escherichia coli
-
 endonuclease III
-
4.2.99.18 Homo sapiens
-
-
-
4.2.99.18 Tequatrovirus T4
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.99.18 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.99.18 DNA
-
 Escherichia coli fragments of DNA
-
 ?
4.2.99.18 DNA
-
 Homo sapiens fragments of DNA
-
 ?
4.2.99.18 DNA
-
 Tequatrovirus T4 fragments of DNA
-
 ?
4.2.99.18 additional information
-
 Homo sapiens ?
-
 ?
4.2.99.18 additional information
-
 Tequatrovirus T4 ?
-
 ?
4.2.99.18 additional information enzyme also has DNA N-glycosylase activity Escherichia coli ?
-
 ?