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Literature summary extracted from

  • Yu, Z.; Schneider, C.; Boeglin, W.E.; Marnett, L.J.; Brash, A.R.
    The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase (2003), Proc. Natl. Acad. Sci. USA, 100, 9162-9167.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.2.1.92 medicine enzyme is involved in skin differentiation and etiology of ichthyosiform diseases Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.152 expressed in Escherichia coli BL21(DE3) cells Homo sapiens
5.4.4.7 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.152 nordihydroguaiaretic acid submicromolar concentrations of nordihydroguaiaretic acid cause a dose-dependent increase in reaction rate 83-4fold with 12R-HPETE and up to 6fold with 15S-HPETE Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.4.4.7 Fe2+ contains Fe2+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.152 (12R)-hydroperoxyeicosatetraenoic acid Homo sapiens preferred substrate (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 ratio ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.92 Homo sapiens
-
-
-
4.2.1.152 Homo sapiens
-
-
-
5.4.4.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.152 Ni-NTA column chromatography Homo sapiens
5.4.4.7 Ni-NTA column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.152 keratinocyte
-
 Homo sapiens
-
5.4.4.7 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.92 (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid poor substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O
-
 ?
4.2.1.92 (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
-
 Homo sapiens (10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O the former being a isomer of hepoxilin A3, ration of products is 2:1 ?
4.2.1.92 (5Z,8Z,11E,13Z,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoic acid poor substrate Homo sapiens 14,15-hepoxilin A3 + 14,15-hepoxilin B3 + H2O
-
 ?
4.2.1.92 (8R)-hydroperoxy-(9Z,12Z)-octadecadienoic acid poor substrate Homo sapiens (7S,8S)-dihydroxy-(9Z,12Z)-octadecadienoic acid + H2O
-
 ?
4.2.1.152 (12R)-hydroperoxyeicosatetraenoic acid preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 ratio ?
4.2.1.152 (12R)-hydroperoxyeicosatetraenoic acid preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 product ratio ?
4.2.1.152 (12S)-hydroperoxyeicosatetraenoic acid
-
 Homo sapiens (10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid
-
 ?
4.2.1.152 (15S)-hydroperoxyeicosatetraenoic acid
-
 Homo sapiens (13R)-hydroxy-(14S,15S)-epoxyeicosa-(5Z,8Z,11Z)-trienoic acid + 12-oxoeicosatetraenoic acid
-
 ?
4.2.1.152 additional information linoleic, arachidonic, and eicosapentaenoic acids, the methyl esters of arachidonic acid and linoleic acid, arachidonyl phosphatidylcholine, anandamide, and the cholesteryl ester of arachidonic acid are no substrates Homo sapiens ?
-
 ?
5.4.4.7 (12R)-HPETE preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 ratio ?
5.4.4.7 (12S)-HPETE
-
 Homo sapiens (10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid
-
 ?
5.4.4.7 (15S)-HPETE
-
 Homo sapiens 15-oxoeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
-
 ?
5.4.4.7 (8R)-HPETE
-
 Homo sapiens ?
-
 ?
5.4.4.7 additional information linoleic, arachidonic, and eicosapentaenoic acids, the methyl esters of arachidonic acid and linoleic acid, arachidonyl phosphatidylcholine, anandamide, and the cholesteryl ester of arachidonic acid are no substrates Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.152 eLOX3
-
 Homo sapiens
4.2.1.152 epidermal LOX type 3
-
 Homo sapiens
5.4.4.7 ALOXE3
-
 Homo sapiens
5.4.4.7 eLOX3
-
 Homo sapiens
5.4.4.7 epidermal LOX type 3
-
 Homo sapiens