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Literature summary extracted from

  • Cane, D.E.; Pawlak, J.L.; Horak, R.M.
    Studies of the cryptic allylic pyrophosphate isomerase activity of trichodiene synthase using the anomalous substrate 6,7-dihydrofarnesyl pyrophosphate (1990), Biochemistry, 29, 5476-5490.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.6 (7R)-(E)-6,7-dihydrofarnesyl diphosphate
-
 Fusarium sporotrichioides
4.2.3.6 (7S)-(E)-6,7-dihydrofarnesyl diphosphate modestly competitive Fusarium sporotrichioides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.6 (E,E)-farnesyl diphosphate Fusarium sporotrichioides
-
 trichodiene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.6 Fusarium sporotrichioides
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.3.6 (2E,6E)-farnesyl diphosphate = trichodiene + diphosphate mechanism Fusarium sporotrichioides
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.6 (7S)-6,7-dihydrofarnesyl diphosphate
-
 Fusarium sporotrichioides dihydrofarnesene isomers + (E)-6,7-dihydrofarnesol + (3S,7S)-6,7-dihydronerolidol
-
 ?
4.2.3.6 (E,E)-farnesyl diphosphate
-
 Fusarium sporotrichioides trichodiene + diphosphate
-
 ?
4.2.3.6 (E,E)-farnesyl diphosphate formation of trichodiene involves initial generation of (3R)-nerolidyl diphosphate Fusarium sporotrichioides trichodiene + diphosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.3.6 0.00022
-
 (7R)-(E)-6,7-dihydrofarnesyl diphosphate
-
 Fusarium sporotrichioides
4.2.3.6 0.000395
-
 (7S)-(E)-6,7-dihydrofarnesyl diphosphate
-
 Fusarium sporotrichioides