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Literature summary extracted from

  • Bazan, J.F.; Fletterick, R.J.
    Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications (1988), Proc. Natl. Acad. Sci. USA, 85, 7872-7876.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.28 additional information no activation by Triton X-100 Enterovirus C

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.28 expressed in Escherichia coli or BL21(D3) Enterovirus C

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.28 1,3-Dibromoacetone
-
 Enterovirus C
3.4.22.28 additional information no inhibition by Triton X-100 Enterovirus C

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.28 soluble recombinant enzyme Enterovirus C
-
-
3.4.22.28 soluble native enzyme: partial Enterovirus C
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.28 20000
-
-
 Enterovirus C

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.28 Enterovirus C
-
 type 2, i.e. Sabin strain
-
3.4.22.28 Enterovirus C Sabin
-
 type 2, i.e. Sabin strain
-
3.4.22.29 coxsackievirus
-
-
-
3.4.22.29 enterovirus
-
 bovine enterovirus
-
3.4.22.29 Enterovirus C
-
 type 1 (Mahoney strain)
-
3.4.22.29 Human rhinovirus sp.
-
 serotypes 2
-
3.4.22.29 Human rhinovirus sp.
-
 serotypes 14
-
3.4.22.29 picornaviridae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.28 recombinant enzyme Enterovirus C

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.28 dansyl-Glu-Glu-Glu-Ala-Met-Glu-Gly-Ile-Thr-Asn-Lys-NH2 + H2O i.e. peptide corresponding to cleavage site between poliovirus polypeptides 2A and 2B Enterovirus C dansyl-Glu-Glu-Glu-Ala-Met-Glu + Gly-Ile-Thr-Asn-Lys-NH2
-
 ?
3.4.22.28 dansyl-Glu-Glu-Glu-Ala-Met-Glu-Gly-Ile-Thr-Asn-Lys-NH2 + H2O i.e. peptide corresponding to cleavage site between poliovirus polypeptides 2A and 2B Enterovirus C Sabin dansyl-Glu-Glu-Glu-Ala-Met-Glu + Gly-Ile-Thr-Asn-Lys-NH2
-
 ?
3.4.22.28 poliovirus P1 precursor polyprotein + H2O trans-cleavage Enterovirus C capsid proteins
-
 ?
3.4.22.28 poliovirus P1 precursor polyprotein + H2O trans-cleavage Enterovirus C Sabin capsid proteins
-
 ?