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Literature summary extracted from
- Action of rat liver cathepsin L on collagen and other substrates (1982), Biochem. J., 201, 376-372.
No PubMed abstract available
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.4.22.15 | very susceptible to loss of activity through autolysis | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.15 | Hg2+ | - |
Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.15 | 0.007 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
Rattus norvegicus | |
| 3.4.22.15 | 0.01 | - |
benzyloxycarbonyl-Lys-p-nitrophenyl ester | - |
Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.15 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.22.15 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.15 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.15 | azocasein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.15 | benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O | weak activity | Rattus norvegicus | ? | - |
? | |
| 3.4.22.15 | benzyloxycarbonyl-Lys-p-nitrophenyl ester + H2O | - |
Rattus norvegicus | benzyloxycarbonyl-Lys + 4-nitrophenol | - |
? | |
| 3.4.22.15 | benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.15 | Collagen + H2O | selective cleavage of terminal peptides leads to conversion of beta- and higher components mainly to alpha-chains | Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.15 | 19.8 | - |
benzyloxycarbonyl-Lys-p-nitrophenyl ester | - |
Rattus norvegicus | |
| 3.4.22.15 | 26 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
Rattus norvegicus | |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.15 | 3.5 | 6 | hydrolysis of collagen is 5fold faster at pH 3.5 than at pH 6.0 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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