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Literature summary extracted from

  • Mason, R.W.; Green, G.D.J.; Barrett, A.J.
    Human liver cathepsin L (1985), Biochem. J., 226, 233-241.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 benzyloxycarbonyl-Phe-Ala-CNH2
-
 Homo sapiens
3.4.22.15 Benzyloxycarbonyl-Phe-Phe-CHN2
-
 Homo sapiens
3.4.22.15 Ep-460
-
 Homo sapiens
3.4.22.15 Ep-475
-
 Homo sapiens
3.4.22.15 leupeptin
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.15 25000
-
 1 * 25000 + 1 * 50000, SDS-PAGE under reducing conditions Homo sapiens
3.4.22.15 50000
-
 1 * 25000 + 1 * 50000, SDS-PAGE under reducing conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.15
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.15 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.15 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 Arg-4-methylcoumarin 7-amide + H2O no activity Homo sapiens Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.15 benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O no activity Homo sapiens ?
-
 ?
3.4.22.15 benzyloxycarbonyl-L-citrulline-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens benzyloxycarbonyl-L-citrulline 7-amino-4-methylcoumarin
-
 ?
3.4.22.15 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.15 additional information no activity with benzyloxycarbonyl-Phe-Ala-4-methylcoumarin 7-amide and with benzyloxycarbonyl-Phe-Met-4-methylcoumarin 7-amide Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.15 dimer 1 * 25000 + 1 * 50000, SDS-PAGE under reducing conditions Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.22.15 37
-
 pH 4.5-5.5, 24 h, more than 70% of the activity is retained Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.22.15 4.5 5.5 37°C, 24 h, more than 70% of the activity is retained Homo sapiens
3.4.22.15 7
-
 15 min, 85% loss of activity Homo sapiens