EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.23.B8 | medicine | the enzyme is an attractive target for inhibitor design | Human T-cell leukemia virus type I |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.B8 | Ac-Leu-Lys-Ala-Gln-Ile-His-Phe | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Ac-Leu-Val-Phe-H | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2 | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Ac-Thr-Leu-Asn-Phe | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Ac-Thr-Val-Ser-Phe-Asn-Phe | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Ala-Pro-Gln-Val-statine-Val-Met-His-Pro | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | MES13-099 | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | additional information | Ac-Thr-Ile-Nle(reduced peptide bond)-Nle-Gln-Arg; Arg-Val-Leu(reduced peptide bond)-Phe-Glu-Ala-Nle-NH2; Ser-Gln-Asn-Phe(reduced peptide bond)-Pro-Ile-Val | Human T-cell leukemia virus type I | |
3.4.23.B8 | Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | tert-butyloxycarbonyl-Val-Val-Phe-Psi[P(O)(OH)]-Phe-Val-Val-NH2 | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu | - |
Human T-cell leukemia virus type I |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.B8 | additional information | - |
additional information | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.014 | - |
PPVMGVLDAP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.02 | - |
PPAILPIISE | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.06 | - |
PQVLPVMHP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.087 | - |
TKVLVVQPK | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.23 | - |
DPASILPVIP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.5 | - |
YVEPTAPQVLPVMHP | - |
Human T-cell leukemia virus type I |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.B8 | additional information | Human T-cell leukemia virus type I | the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.B8 | Human T-cell leukemia virus type I | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.B8 | APQVLPVMHPHG + H2O | - |
Human T-cell leukemia virus type I | APQVL + PVMHPHG | - |
? | |
3.4.23.B8 | DPASILPVIP + H2O | - |
Human T-cell leukemia virus type I | DPASIL + PVIP | - |
? | |
3.4.23.B8 | KGPPVILPIQAP + H2O | - |
Human T-cell leukemia virus type I | KGPPVIL + PIQAP | - |
? | |
3.4.23.B8 | KQPAILVHTPG + H2O | - |
Human T-cell leukemia virus type I | KQPAIL + VHTPG | - |
? | |
3.4.23.B8 | KTKVLVVQPK + H2O | - |
Human T-cell leukemia virus type I | KTKVL + VVQPK | - |
? | |
3.4.23.B8 | additional information | the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication | Human T-cell leukemia virus type I | ? | - |
? | |
3.4.23.B8 | PPAILPIISE + H2O | - |
Human T-cell leukemia virus type I | PPAIL + PIISE | - |
? | |
3.4.23.B8 | PPVMGVLDAP + H2O | - |
Human T-cell leukemia virus type I | PPVMG + VLDAP | - |
? | |
3.4.23.B8 | PQVLPVMHP + H2O | - |
Human T-cell leukemia virus type I | PQVL + PVMHP | - |
? | |
3.4.23.B8 | TKVLVVQPK + H2O | - |
Human T-cell leukemia virus type I | TKVL + VVQPK | - |
? | |
3.4.23.B8 | VSQNYPIVQ + H2O | - |
Human T-cell leukemia virus type I | VSQNY + PIVQ | - |
? | |
3.4.23.B8 | YVEPTAPQVLPVMHP + H2O | - |
Human T-cell leukemia virus type I | ? | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.B8 | additional information | - |
additional information | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.00833 | - |
PPVMGVLDAP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.085 | - |
YVEPTAPQVLPVMHP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.22 | - |
PQVLPVMHP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.7 | - |
DPASILPVIP | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 2.7 | - |
TKVLVVQPK | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 3.3 | - |
PPAILPIISE | - |
Human T-cell leukemia virus type I |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.B8 | 0.000006 | - |
Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.00005 | - |
Ala-Pro-Gln-Val-statine-Val-Met-His-Pro | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.00008 | - |
tert-butyloxycarbonyl-Val-Val-Phe[P(O)(OH)-]-Phe-Val-Val-NH2 | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.00024 | - |
MES13-099 | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.0057 | - |
Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.0506 | - |
Ac-Leu-Lys-Ala-Gln-Ile-His-Phe | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.07 | - |
Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.0872 | - |
Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.093 | - |
Ac-Leu-Val-Phe-H | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.217 | - |
Ac-Thr-Val-Ser-Phe-Asn-Phe | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 0.252 | - |
Ac-Thr-Leu-Asn-Phe | - |
Human T-cell leukemia virus type I | |
3.4.23.B8 | 1.7 | - |
Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2 | - |
Human T-cell leukemia virus type I |