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Literature summary extracted from

  • Beck, Z.Q.; Lin, Y.C.; Elder, J.H.
    Molecular basis for the relative substrate specificity of human immunodeficiency virus type 1 and feline immunodeficiency virus proteases (2001), J. Virol., 75, 9458-9469.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.B4 Ac-Gly-Ser-Gly-Val-Phe-Psi[CH2NH2]-Val-Val-Asn-Gly-Leu
-
 feline immunodeficiency virus
3.4.23.B4 Gly-Ser-Gly-Val-Phe[CH2NH]-Val-Val-Asn-Gly-Leu IC50: 0.0004 mM feline immunodeficiency virus
3.4.23.B4 Gly-Ser-Gly-Val-Phe[CHOHCH2]-Val-Val-Asn-Gly-Leu IC50: 0.005 mM feline immunodeficiency virus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.B4 0.013
-
 Arg-Ala-Leu-Thr-Lys-(4-aminobenzoic acid)-Val-Gln-Phe-(NO2)-Val-Gln-Ser-Lys-Gly-Arg-NH2
-
 feline immunodeficiency virus

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.B4 feline immunodeficiency virus P16088
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.B4 Ac-Lys-Ser-Gly-Val-Phe-Val-Val-Asn-Gly-Lys-NH2 + H2O
-
 feline immunodeficiency virus Ac-Lys-Ser-Gly-Val-Phe + Val-Val-Asn-Gly-Lys-NH2
-
 ?
3.4.23.B4 Arg-Ala-Leu-Thr-Lys-(4-aminobenzoic acid)-Val-Gln-Phe-(NO2)-Val-Gln-Ser-Lys-Gly-Arg-NH2 + H2O
-
 feline immunodeficiency virus Arg-Ala-Leu-Thr-Lys-(4-aminobenzoic acid)-Val-Gln + Phe-(NO2)-Val-Gln-Ser-Lys-Gly-Arg-NH2
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Ala-Leu-Thr-Asn-Ala-Val-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Ala-Leu-Thr-Asn + Ala-Val-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Ala-Met-Val-Asn-Gln-Ala-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Ala-Met-Val-Asn + Gln-Ala-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Gly-Arg-Ile-Asn-Val-Ala-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Gly-Arg-Ile-Asn + Val-Ala-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Ile-Tyr-Thr-Val-Gln-Ser-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Ile-Tyr + Thr-Val-Gln-Ser-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Leu-Thr-Met-Val-Thr-Gln-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Leu-Thr-Met + Val-Thr-Gln-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Thr-Trp-Met-Val-His-Ser-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Thr-Trp + Met-Val-His-Ser-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Val-Phe-Ala-Val-Thr-Gln-Leu-Val-Pro-Lys + H2O
-
 feline immunodeficiency virus Lys-Gly-Ser-Gly-Val-Phe + Ala-Val-Thr-Gln-Leu-Val-Pro-Lys
-
 ?
3.4.23.B4 Lys-Gly-Ser-Gly-Val-Tyr-Gln-Leu-Ser-Ala-Leu-Val-Pro-Lys two cleavage sites: Tyr-Gln and Leu-Ser feline immunodeficiency virus ?
-
 ?
3.4.23.B4 Lys-Ser-Gly-Ile-Phe-Val-Val-Asn-Gly-Leu-Val-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Ile-Phe + Val-Val-Asn-Gly-Leu-Val-Lys
-
 ?
3.4.23.B4 Lys-Ser-Gly-Val-Phe-His-Val-Asn-Gly-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Val-Phe + His-Val-Asn-Gly-Lys
-
 ?
3.4.23.B4 Lys-Ser-Gly-Val-Phe-Ser-Val-Asn-Gly-Leu-Val-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Val-Phe + Ser-Val-Asn-Gly-Leu-Val-Lys
-
 ?
3.4.23.B4 Lys-Ser-Gly-Val-Phe-Val-Val-Asn-Gly-Leu-Val-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Val-Phe + Val-Val-Asn-Gly-Leu-Val-Lys
-
 ?
3.4.23.B4 Lys-Ser-Gly-Val-Phe-Val-Val-Asn-Gly-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Val-Phe + Val-Val-Asn-Gly-Lys
-
 ?
3.4.23.B4 Lys-Ser-Gly-Val-Phe-Val-Val-Gln-Gly-Leu-Val-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Val-Phe + Val-Val-Gln-Gly-Leu-Val-Lys
-
 ?
3.4.23.B4 Lys-Ser-Gly-Val-Phe-Val-Val-Thr-Gly-Leu-Val-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Gly-Val-Phe + Val-Val-Thr-Gly-Leu-Val-Lys
-
 ?
3.4.23.B4 Lys-Ser-Phe-Val-Phe-Val-Val-Asn-Gly-Leu-Val-Lys + H2O
-
 feline immunodeficiency virus Lys-Ser-Phe-Val-Phe + Val-Val-Asn-Gly-Leu-Val-Lys
-
 ?
3.4.23.B4 additional information cleavage of the HIV-1 protease substrate (4-aminobenzoic acid)-Thr-Ile-Nle-Phe-(NO2)-Gln-Arg-NH2 is undetectable after 1 h feline immunodeficiency virus ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.23.B4 0.11
-
 Arg-Ala-Leu-Thr-Lys-(4-aminobenzoic acid)-Val-Gln-Phe-(NO2)-Val-Gln-Ser-Lys-Gly-Arg-NH2
-
 feline immunodeficiency virus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.23.B4 0.0004
-
 IC50: 0.0004 mM feline immunodeficiency virus Gly-Ser-Gly-Val-Phe[CH2NH]-Val-Val-Asn-Gly-Leu
3.4.23.B4 0.005
-
 IC50: 0.005 mM feline immunodeficiency virus Gly-Ser-Gly-Val-Phe[CHOHCH2]-Val-Val-Asn-Gly-Leu