Literature summary extracted from

Mohr, S.; Zech, B.; Lapetina, E.G.; Brune, B.
Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide (1997), Biochem. Biophys. Res. Commun., 238, 387-391.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.56	3-morpholinosydnonimine	i.e. SIN-1, 1 mM, complete inhibition	Homo sapiens
3.4.22.56	BF4NO	0.1 mM, complete inhibition	Homo sapiens
3.4.22.56	iodoacetamide	-	Homo sapiens
3.4.22.56	m-(acetyl-L-Asp-L-Val-NH)-N-nitroso-N-phenylglycine	-	Homo sapiens
3.4.22.56	N-acetyl-L-aspartyl-L-valyl-N-[(1S)-2-carboxy-1-[[(4-methylphenyl)(nitroso)amino]methyl]ethyl]-L-alaninamide	-	Homo sapiens
3.4.22.56	NEM	-	Homo sapiens
3.4.22.56	peroxynitrite	0.01 mM, 50% inhibition	Homo sapiens
3.4.22.56	S-nitrosoglutathione	0.1 mM, complete inhibition	Homo sapiens
3.4.22.56	spermine-NO	1 mM, complete inhibition	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.56	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.56	U-937 cell	promyelocytic leukemia	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.56	acetyl-DEVD-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	acetyl-DEVD + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)