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Literature summary extracted from

  • Rehault, S.; Brillard-Bourdet, M.; Bourgois, L.; Frenette, G.; Juliano, L.; Gauthier, F.; Moreau, T.
    Design of new and sensitive fluorogenic substrates for human kallikrein hK3 (prostate-specific antigen) derived from semenogelin sequences (2002), Biochim. Biophys. Acta, 1596, 55-62.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.77 medicine used in the diagnosis of prostate cancer Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.77 extracellular secretion Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.77 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?
3.4.21.77 semenogelin + H2O Homo sapiens
-
 semenogelin fractions
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.77 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.77
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.77 Preferential cleavage: -Tyr-/- enzyme is a serine protease Homo sapiens
a
3.4.21.77 Preferential cleavage: -Tyr-/- enzyme shows chymotrypsin-like activity Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.77 seminal plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.77 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.77 o-aminobenzoyl-ISYQSSSTEEQ ethylene diamine 2,4-dinitrophenyl + H2O substrate is intramolecularly quenched Homo sapiens o-aminobenzoyl-ISY + QSSSTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-ISYQSSSTEEQ ethylene diamine 2,4-dinitrophenyl + H2O synthetic fluorogenic substrate Homo sapiens o-aminobenzoyl-ISY + QSSSTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-NKISYQSSSQ ethylene diamine 2,4-dinitrophenyl + H2O substrate is intramolecularly quenched Homo sapiens o-aminobenzoyl-NKISY + Q + SSSQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-NKISYQSSSQ ethylene diamine 2,4-dinitrophenyl + H2O synthetic fluorogenic substrate Homo sapiens o-aminobenzoyl-NKISY + Q + SSSQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-SSIYSNTEEQ ethylene diamine 2,4-dinitrophenyl + H2O substrate is intramolecularly quenched Homo sapiens o-aminobenzoyl-SSIY + SNTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-SSIYSNTEEQ ethylene diamine 2,4-dinitrophenyl + H2O synthetic fluorogenic substrate Homo sapiens o-aminobenzoyl-SSIY + SNTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-SSIYSNTEEQ ethylene diamine 2,4-dinitrophenyl + H2O sequence contains ex vivo cleavage sites of semenogelin I Homo sapiens o-aminobenzoyl-SSIY + SNTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-SSQYSNTEEQ ethylene diamine 2,4-dinitrophenyl + H2O substrate is intramolecularly quenched Homo sapiens o-aminobenzoyl-SSQY + SNTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-SSQYSNTEEQ ethylene diamine 2,4-dinitrophenyl + H2O synthetic fluorogenic substrate Homo sapiens o-aminobenzoyl-SSQY + SNTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 o-aminobenzoyl-SSQYSNTEEQ ethylene diamine 2,4-dinitrophenyl + H2O sequence contains ex vivo cleavage sites of semenogelin I Homo sapiens o-aminobenzoyl-SSQY + SNTEEQ ethylene diamine 2,4-dinitrophenyl
-
 ?
3.4.21.77 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.77 semenogelin + H2O
-
 Homo sapiens semenogelin fragments
-
 ?
3.4.21.77 semenogelin + H2O
-
 Homo sapiens semenogelin fractions
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.77 K3
-
 Homo sapiens
3.4.21.77 prostate-specific antigen
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.77 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.77 8.3
-
 assay at Homo sapiens