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Literature summary extracted from

  • Kawamura, T.; Okada, N.; Okada, H.
    Elastase from activated human neutrophils activates procarboxypeptidase R (2002), Microbiol. Immunol., 46, 225-230.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 procarboxypeptidase R + H2O Homo sapiens generation of activated carboxypeptidase R from procarboxypeptidase R by elastase from activated neutrophils at the site of inflammation should contribute to the suppression of excessive inflammation and any abnormality in this mechanism can induce serious hyper-inflammation such as seen in multiple organ failure carboxypeptidase R + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.20 Homo sapiens
-
-
-
3.4.21.37 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.20 proteolytic modification elastase can activate pro-carboxypeptidase R directly or indirectly through activation of some proteases Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.20 blood plasma
-
 Homo sapiens
-
3.4.21.37 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.20 hippuryl-Arg + H2O
-
 Homo sapiens hippuric acid + Arg
-
 ?
3.4.21.37 procarboxypeptidase R + H2O generation of activated carboxypeptidase R from procarboxypeptidase R by elastase from activated neutrophils at the site of inflammation should contribute to the suppression of excessive inflammation and any abnormality in this mechanism can induce serious hyper-inflammation such as seen in multiple organ failure Homo sapiens carboxypeptidase R + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.20 CPR
-
 Homo sapiens