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Literature summary extracted from
- Human lysosomal elastase. Catalytic and immunological properties (1976), Biochem. J., 155, 265-271.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.37 | acetyl-Ala-Ala-Ala-Ala-CH2Cl | - |
Homo sapiens |  |
| 3.4.21.37 | acetyl-Ala-Ala-Pro-Ala-CH2Cl | - |
Homo sapiens | |
| 3.4.21.37 | Cys | - |
Homo sapiens | |
| 3.4.21.37 | diisopropyl phosphorofluoridate | - |
Homo sapiens | |
| 3.4.21.37 | gold thiomalate | inhibition is abolished by 1.0 M KCl | Homo sapiens | |
| 3.4.21.37 | NaCl | 1.0 M, 50% inhibition | Homo sapiens | |
| 3.4.21.37 | ovomucoid | chicken ovomucoid; turkey ovomucoid | Homo sapiens | |
| 3.4.21.37 | phenylmethylsulfonyl fluoride | - |
Homo sapiens | |
| 3.4.21.37 | tosyl-Lys-CH2Cl | weak | Homo sapiens | |
| 3.4.21.37 | Trypsin inhibitor | lima-bean trypsin inhibitor; soya-bean trypsin inhibitor | Homo sapiens | |
| 3.4.21.37 | ZnSO4 | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.37 | lysosome | - |
Homo sapiens | 5764 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | spleen | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | 2-(chloroacetyl)-3-naphthoic acid o-toluidide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | azocasein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | benzyloxycarbonyl-L-Ala 2-naphthyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Ala + 2-naphthol | - |
? | |
| 3.4.21.37 | Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | tert-butyloxycarbonyl-Ala-2-naphthyl ester + H2O | - |
Homo sapiens | tert-butyloxycarbonyl-Ala + 2-naphthol | - |
? | |
| 3.4.21.37 | tert-butyloxycarbonyl-Ala-4-nitrophenyl ester + H2O | - |
Homo sapiens | tert-butyloxycarbonyl-Ala + 4-nitrophenol | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.37 | 8.2 | 9.2 | hydrolysis of azocasein or benzyloxycarbonyl-L-Ala 2-naphthyl ester | Homo sapiens |
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