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Literature summary extracted from

  • Cloutier, S.M.; Chagas, J.R.; Mach, J.P.; Gygi, C.M.; Leisinger, H.J.; Deperthes, D.
    Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology (2002), Eur. J. Biochem., 269, 2747-2754.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.35 additional information Homo sapiens involved in prostate cancer development ?
-
 ?
3.4.21.35 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.35 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.35 Preferential cleavage of Arg-/- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-/- or Leu-/-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-/- bonds strict preference for Arg in P1 position, wich is further enhanced by Ser in P1' position Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.35 96.5
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.35 D-Val-Leu-Arg-p-nitroanilide + H2O weak activity Homo sapiens D-Val-Leu-Arg + p-nitroaniline
-
 ?
3.4.21.35 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.35 additional information substrate specificty study by phage display Homo sapiens ?
-
 ?
3.4.21.35 additional information involved in prostate cancer development Homo sapiens ?
-
 ?
3.4.21.35 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.35 protein C inhibitor + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.35 semenogelin I + H2O
-
 Homo sapiens semenogelin I fragments
-
 ?
3.4.21.35 semenogelin II + H2O
-
 Homo sapiens semenogelin II fragments
-
 ?