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Literature summary extracted from

  • Clements, J.; Hooper, J.; Dong, Y.; Harvey, T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions (2001), Biol. Chem., 382, 5-14.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.35 genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.35 kininogen + H2O Homo sapiens
-
 kallidin + kinin heavy chain + kinin light chain
-
 ?
3.4.21.35 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.35 Homo sapiens P06870 gene KLK1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.35 endometrium
-
 Homo sapiens
-
3.4.21.35 kidney
-
 Homo sapiens
-
3.4.21.35 ovary
-
 Homo sapiens
-
3.4.21.35 pancreas
-
 Homo sapiens
-
3.4.21.35 salivary gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.35 kininogen + H2O
-
 Homo sapiens kallidin + kinin heavy chain + kinin light chain
-
 ?
3.4.21.35 low-molecular-weight kininogen + H2O
-
 Homo sapiens kallidin + kinin kallidin is Lys-bradykinin ?
3.4.21.35 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.35 K1
-
 Homo sapiens
3.4.21.35 tissue kallikrein
-
 Homo sapiens