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Literature summary extracted from

  • Forteza, R.; Lauredo, I.; Abraham, W.M.; Conner, G.E.
    Bronchial tissue kallikrein activity is regulated by hyaluronic acid binding (1999), Am. J. Respir. Cell Mol. Biol., 21, 666-674.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.35 chymase stimulation, in correlation with secretory leukoprotease inhibitor stimulation, in stimulated serous cells Ovis aries
3.4.21.35 hyaluronidase increases K2 enzyme activity by digesting the K2-bound hyaluronic acid Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.35 hyaluronic acid binds to the enzyme in vivo Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.35 extracellular secretion by serous cells Ovis aries
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.35 polypeptide + H2O Ovis aries
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.35 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.35 partial Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.35 cell culture primary, tracheal submucosal gland Ovis aries
-
3.4.21.35 mucous gland tracheal, primary cell culture Ovis aries
-
3.4.21.35 serous gland
-
 Ovis aries
-
3.4.21.35 trachea submucosal gland, primary cell culture Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.35 D-Val-Leu-Arg-p-nitroanilide + H2O
-
 Ovis aries D-Val-Leu-Arg + p-nitroaniline
-
 ?
3.4.21.35 kininogen + H2O high-molecular weight kininogen Ovis aries bradykinin + kinin heavy chain + kinin light chain
-
 ?
3.4.21.35 kininogen + H2O 3 additional cleavage sites at Arg427, Arg437, and Arg457 Ovis aries bradykinin + kinin heavy chain + kinin light chain
-
 ?
3.4.21.35 polypeptide + H2O
-
 Ovis aries peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.35 TK
-
 Ovis aries

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.35 37
-
 assay at Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.35 8.2
-
 assay at Ovis aries