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Literature summary extracted from

  • Del Nery, E.; Chagas, J.R.; Juliano, M.A.; Juliano, L.; Prado, E.S.
    Comparison of human and porcine tissue kallikrein substrate specificities (1999), Immunopharmacology, 45, 151-157.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.35 0.0002
-
 o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.0003
-
 o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.00035
-
 o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.0004
-
 o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.00041
-
 o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.00051
-
 o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0006
-
 o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.00076
-
 o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0009
-
 o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.0014
-
 o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0023
-
 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.0039
-
 o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0042
-
 o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.0047
-
 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0067
-
 o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.0073
-
 o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0104
-
 o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.0455
-
 o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.35 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?
3.4.21.35 polypeptide + H2O Sus scrofa
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.35 Homo sapiens
-
-
-
3.4.21.35 Sus scrofa
-
 form B
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.35 additional information substrate specificity study Homo sapiens ?
-
 ?
3.4.21.35 additional information substrate specificity study Sus scrofa ?
-
 ?
3.4.21.35 o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in human kininogen Homo sapiens o-aminobenzoyl-FR + SSR-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in human kininogen Sus scrofa o-aminobenzoyl-FR + SSR-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in bovine kininogen Homo sapiens o-aminobenzoyl-FR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in bovine kininogen Sus scrofa o-aminobenzoyl-FR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in human kininogen Homo sapiens o-aminobenzoyl-GFSPFR + SSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in human kininogen Sus scrofa o-aminobenzoyl-GFSPFR + SSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in human kininogen Homo sapiens o-aminobenzoyl-GFSPFR + SSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in human kininogen Sus scrofa o-aminobenzoyl-GFSPFR + SSRQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in bovine kininogen Homo sapiens o-aminobenzoyl-GFSPFR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in bovine kininogen Sus scrofa o-aminobenzoyl-GFSPFR + SVQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in bovine kininogen Homo sapiens o-aminobenzoyl-GFSPFR + SVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Arg-Ser bond in bovine kininogen Sus scrofa o-aminobenzoyl-GFSPFR + SVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O low activity Homo sapiens o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O low activity Sus scrofa o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Met-Lys bond in human and bovine kininogen Homo sapiens o-aminobenzoyl-LM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Met-Lys bond in human kininogen Homo sapiens o-aminobenzoyl-QPLGMISLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Met-Lys bond in human kininogen Sus scrofa o-aminobenzoyl-QPLGMISLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Met-Lys bond in bovine kininogen Homo sapiens o-aminobenzoyl-QPLGQTSLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine + H2O sequence spanning the scissile Met-Lys bond in bovine kininogen Sus scrofa o-aminobenzoyl-QPLGQTSLM + KRP-N-(2,4-dinitrophenyl)ethylene diamine
-
 ?
3.4.21.35 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.35 polypeptide + H2O
-
 Sus scrofa peptides
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.35 30
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.35 0.04
-
 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.076
-
 o-aminobenzoyl-LMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.4
-
 o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.6
-
 o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 0.9
-
 o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 0.94
-
 o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 1
-
 o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 1.1
-
 o-aminobenzoyl-QPLGQTSLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 1.4
-
 o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 1.5
-
 o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 1.6
-
 o-aminobenzoyl-FRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 3
-
 o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 3.1
-
 o-aminobenzoyl-GFSPFRSSRIGEIKEEQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 4
-
 o-aminobenzoyl-GFSPFRSVQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 7
-
 o-aminobenzoyl-FRSSR-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa
3.4.21.35 7.1
-
 o-aminobenzoyl-QPLGMISLMKRP-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 7.5
-
 o-aminobenzoyl-GFSPFRSSRQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Homo sapiens
3.4.21.35 40.1
-
 o-aminobenzoyl-GFSPFRSVQVMKYEGSQ-N-(2,4-dinitrophenyl)ethylene diamine pH 9.0, 30°C Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.35 9
-
 assay at Homo sapiens
3.4.21.35 9
-
 assay at Sus scrofa