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Literature summary extracted from

  • van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
    Characterization of seven murine caspase family members (1997), FEBS Lett., 403, 61-69.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.36
-
 Mus musculus
3.4.22.55
-
 Mus musculus
3.4.22.56
-
 Mus musculus
3.4.22.59
-
 Mus musculus
3.4.22.60
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.36 additional information Mus musculus the enzyme induces apoptosis in transfected cells ?
-
 ?
3.4.22.36 additional information Mus musculus C3H/An the enzyme induces apoptosis in transfected cells ?
-
 ?
3.4.22.36 pro-interleukin-1beta + H2O Mus musculus pIL-1beta is mainly processed by caspase-1, but also by caspase-3 17000 Da fragment + 28000 Da fragment
-
 ?
3.4.22.36 pro-interleukin-1beta + H2O Mus musculus C3H/An pIL-1beta is mainly processed by caspase-1, but also by caspase-3 17000 Da fragment + 28000 Da fragment
-
 ?
3.4.22.56 poly(ADP-ribose) polymerase + H2O Mus musculus caspase-3 is the predominant poly(ADP-ribose) polymerase cleaving enzyme 85000 Da fragment + ?
-
 ?
3.4.22.56 poly(ADP-ribose) polymerase + H2O Mus musculus C3H/An caspase-3 is the predominant poly(ADP-ribose) polymerase cleaving enzyme 85000 Da fragment + ?
-
 ?
3.4.22.59 additional information Mus musculus overexpression induces apoptosis ?
-
 ?
3.4.22.60 additional information Mus musculus overexpression induces apoptosis ?
-
 ?
3.4.22.64 additional information Mus musculus
-
 ?
-
 ?
3.4.22.64 additional information Mus musculus C3H/An
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.36 Mus musculus P29452
-
-
3.4.22.36 Mus musculus C3H/An P29452
-
-
3.4.22.55 Mus musculus P29594 C3H/An
-
3.4.22.55 Mus musculus C3H/An P29594 C3H/An
-
3.4.22.56 Mus musculus P70677
-
-
3.4.22.56 Mus musculus C3H/An P70677
-
-
3.4.22.57 Mus musculus P70343
-
-
3.4.22.59 Mus musculus O08738
-
-
3.4.22.60 Mus musculus P97864
-
-
3.4.22.64 Mus musculus P70343
-
-
3.4.22.64 Mus musculus C3H/An P70343
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.36 brain low activity Mus musculus
-
3.4.22.36 heart low activity Mus musculus
-
3.4.22.36 kidney low activity Mus musculus
-
3.4.22.36 liver low activity Mus musculus
-
3.4.22.36 lung
-
 Mus musculus
-
3.4.22.36 skeletal muscle low activity Mus musculus
-
3.4.22.36 spleen
-
 Mus musculus
-
3.4.22.36 testis low activity Mus musculus
-
3.4.22.55 heart
-
 Mus musculus
-
3.4.22.55 kidney
-
 Mus musculus
-
3.4.22.55 liver
-
 Mus musculus
-
3.4.22.55 lung
-
 Mus musculus
-
3.4.22.55 skeletal muscle low activity Mus musculus
-
3.4.22.55 spleen
-
 Mus musculus
-
3.4.22.55 testis
-
 Mus musculus
-
3.4.22.56 brain
-
 Mus musculus
-
3.4.22.56 heart
-
 Mus musculus
-
3.4.22.56 kidney
-
 Mus musculus
-
3.4.22.56 liver
-
 Mus musculus
-
3.4.22.56 lung
-
 Mus musculus
-
3.4.22.56 skeletal muscle
-
 Mus musculus
-
3.4.22.56 spleen
-
 Mus musculus
-
3.4.22.57 heart
-
 Mus musculus
-
3.4.22.57 kidney low activity Mus musculus
-
3.4.22.57 liver low activity Mus musculus
-
3.4.22.57 lung
-
 Mus musculus
-
3.4.22.57 additional information no activity detected in brain Mus musculus
-
3.4.22.57 skeletal muscle low activity Mus musculus
-
3.4.22.57 spleen
-
 Mus musculus
-
3.4.22.57 testis low activity Mus musculus
-
3.4.22.59 brain low activity Mus musculus
-
3.4.22.59 heart
-
 Mus musculus
-
3.4.22.59 kidney
-
 Mus musculus
-
3.4.22.59 liver
-
 Mus musculus
-
3.4.22.59 lung
-
 Mus musculus
-
3.4.22.59 skeletal muscle low activity Mus musculus
-
3.4.22.59 spleen
-
 Mus musculus
-
3.4.22.59 testis
-
 Mus musculus
-
3.4.22.60 brain low activity Mus musculus
-
3.4.22.60 heart
-
 Mus musculus
-
3.4.22.60 kidney
-
 Mus musculus
-
3.4.22.60 liver
-
 Mus musculus
-
3.4.22.60 lung
-
 Mus musculus
-
3.4.22.60 skeletal muscle
-
 Mus musculus
-
3.4.22.60 spleen
-
 Mus musculus
-
3.4.22.60 testis
-
 Mus musculus
-
3.4.22.64 heart
-
 Mus musculus
-
3.4.22.64 kidney low activity Mus musculus
-
3.4.22.64 liver low activity Mus musculus
-
3.4.22.64 lung
-
 Mus musculus
-
3.4.22.64 additional information no activity detected in brain Mus musculus
-
3.4.22.64 skeletal muscle low activity Mus musculus
-
3.4.22.64 spleen
-
 Mus musculus
-
3.4.22.64 testis low activity Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.36 additional information the enzyme induces apoptosis in transfected cells Mus musculus ?
-
 ?
3.4.22.36 additional information the enzyme induces apoptosis in transfected cells Mus musculus C3H/An ?
-
 ?
3.4.22.36 pre-interleukin-1beta + H2O
-
 Mus musculus 17000 Da fragment + 28000 Da fragment
-
 ?
3.4.22.36 pre-interleukin-1beta + H2O
-
 Mus musculus C3H/An 17000 Da fragment + 28000 Da fragment
-
 ?
3.4.22.36 pro-interleukin-1beta + H2O pIL-1beta is mainly processed by caspase-1, but also by caspase-3 Mus musculus 17000 Da fragment + 28000 Da fragment
-
 ?
3.4.22.36 pro-interleukin-1beta + H2O pIL-1beta is mainly processed by caspase-1, but also by caspase-3 Mus musculus C3H/An 17000 Da fragment + 28000 Da fragment
-
 ?
3.4.22.56 poly(ADP-ribose) polymerase + H2O
-
 Mus musculus ?
-
 ?
3.4.22.56 poly(ADP-ribose) polymerase + H2O
-
 Mus musculus C3H/An ?
-
 ?
3.4.22.56 poly(ADP-ribose) polymerase + H2O caspase-3 is the predominant poly(ADP-ribose) polymerase cleaving enzyme Mus musculus 85000 Da fragment + ?
-
 ?
3.4.22.56 poly(ADP-ribose) polymerase + H2O caspase-3 is the predominant poly(ADP-ribose) polymerase cleaving enzyme Mus musculus C3H/An 85000 Da fragment + ?
-
 ?
3.4.22.56 pre-interleukin-1beta + H2O
-
 Mus musculus additional information a 28000 Da fragement and a 17000 Da fragement, less efficient hydrolysis than with caspase-1 ?
3.4.22.56 pre-interleukin-1beta + H2O
-
 Mus musculus C3H/An additional information a 28000 Da fragement and a 17000 Da fragement, less efficient hydrolysis than with caspase-1 ?
3.4.22.59 additional information overexpression induces apoptosis Mus musculus ?
-
 ?
3.4.22.60 additional information overexpression induces apoptosis Mus musculus ?
-
 ?
3.4.22.64 additional information
-
 Mus musculus ?
-
 ?
3.4.22.64 additional information
-
 Mus musculus C3H/An ?
-
 ?