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Literature summary extracted from

  • Yousef G.M.; Chang A.; Diamandis E.P.
    Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues (2000), J. Biol. Chem., 275, 11891-11898.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.119 medicine gene may be involved in the pathogenesis and/or progression of breast cancer and may find applicability as cancer biomarker Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.119 gene KLK-L4, DNA sequence determination and analysis, gene mapps to chromosome 19q13.3-q13.4, tissue expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.119 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.119 Homo sapiens Q9UKR3 GenBank: AF135024; kallikrein-like gene 4, i.e. KLK-L4
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.119 Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin enzyme is a serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.119 breast
-
 Homo sapiens
-
3.4.21.119 breast carcinoma cell down-regulated by steroid hormones Homo sapiens
-
3.4.21.119 additional information gene is expressed in various tissues Homo sapiens
-
3.4.21.119 prostate
-
 Homo sapiens
-
3.4.21.119 salivary gland
-
 Homo sapiens
-
3.4.21.119 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.119 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?