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Literature summary extracted from

  • Nakayama, K.; Kim, W.S.; Hatsuzawa, K.; Hashiba, K.; Murakami, K.
    Tissue distribution and characterization of prorenin-converting enzyme in mouse (1989), Biochem. Biophys. Res. Commun., 158, 369-376.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.119 antipain
-
 Mus musculus
3.4.21.119 benzamidine
-
 Mus musculus
3.4.21.119 leupeptin
-
 Mus musculus
3.4.21.119 additional information little or no effect by the following protease inhibitors: PMSF, DFP, aprotinin, iodoacetamide, NEM, PCMBS, and E-64; no inhibition by EDTA and pepstatin A Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.119 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.119 polypeptide + H2O Mus musculus
-
 peptides
-
 ?
3.4.21.119 Prorenin + H2O Mus musculus inactive precursor Renin + ? product is an active enzyme ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.119 Mus musculus
-
 female and male ICR mice, Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.119 kidney low activity Mus musculus
-
3.4.21.119 additional information no activity in liver, brain, heart, and pancreas Mus musculus
-
3.4.21.119 submandibular gland highest activity Mus musculus
-
3.4.21.119 submandibular gland enzyme regulation is parallel and similar to that of renin Mus musculus
-
3.4.21.119 submandibular gland larger amounts in male than female mice Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.119 polypeptide + H2O
-
 Mus musculus peptides
-
 ?
3.4.21.119 polypeptide + H2O cleavage site at paired basic amino acid residues Mus musculus peptides
-
 ?
3.4.21.119 Prorenin + H2O cleavage site at paired basic amino acid residues Mus musculus Renin + ?
-
 ?
3.4.21.119 Prorenin + H2O murine or human origin substrate from Xenopus oocytes expression system Mus musculus Renin + ?
-
 ?
3.4.21.119 Prorenin + H2O inactive precursor Mus musculus Renin + ? product is an active enzyme ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.119 More enzyme is neither trypsin-like nor kallikrein Mus musculus
3.4.21.119 prorenin-converting enzyme
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.119 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.119 8 8.5
-
 Mus musculus