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Literature summary extracted from
- Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression (1996), Cancer Res., 56, 3371-3379.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.B41 | DNA and amino acid sequence determination, in vitro translation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B41 | polypeptide + H2O | Homo sapiens | activity is down-regulated during oncogenic transformation | peptides | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.B41 | Homo sapiens | O43240 | gene KLK10 or PRRSL or NES1 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.B41 | colon | gene expression | Homo sapiens | - |
| 3.4.21.B41 | heart | barely detectable gene expression | Homo sapiens | - |
| 3.4.21.B41 | lung | gene expression | Homo sapiens | - |
| 3.4.21.B41 | mammary carcinoma cell | - |
Homo sapiens | - |
| 3.4.21.B41 | mammary epithelium | normal strain 76N and oncogenically transforming strain 76R-30 | Homo sapiens | - |
| 3.4.21.B41 | additional information | gene expression is almost lost in breast cancer cell lines | Homo sapiens | - |
| 3.4.21.B41 | additional information | no expression in fibroblasts, peripheral blood leukocytes, brain, placenta, lung, liver, skeletal muscle, and kidney | Homo sapiens | - |
| 3.4.21.B41 | ovary | gene expression | Homo sapiens | - |
| 3.4.21.B41 | prostate | gene expression | Homo sapiens | - |
| 3.4.21.B41 | small intestine | gene expression | Homo sapiens | - |
| 3.4.21.B41 | testis | gene expression | Homo sapiens | - |
| 3.4.21.B41 | thymus | barely detectable gene expression | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B41 | polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
| 3.4.21.B41 | polypeptide + H2O | activity is down-regulated during oncogenic transformation | Homo sapiens | peptides | - |
? | |
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