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Literature summary extracted from

  • Ekholm, I.E.; Brattsand, M.; Egelrud, T.
    Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process? (2000), J. Invest. Dermatol., 114, 56-63.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B39 cloned from RNA isolated from HaCaT cells, expression as His-tagged enzyme in Escherichia coli BL21(DE3) Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B39 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B39 Homo sapiens Q9Y337 gene KLK5 or SCTE
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B39 recombinant as His-tagged enzyme from Escherichia coli BL21(DE3) Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.B39 proteolytic cleavage of polypeptides enzyme is a serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B39 epidermis interfollicular epidermis Homo sapiens
-
3.4.21.B39 hair follicle interfollicular epidermis Homo sapiens
-
3.4.21.B39 hair follicle terminal Homo sapiens
-
3.4.21.B39 sebaceous follicle
-
 Homo sapiens
-
3.4.21.B39 skin substructure distribution Homo sapiens
-
3.4.21.B39 stratum corneum plantar Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B39 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B39 SCTE
-
 Homo sapiens