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Literature summary extracted from
- Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation (1999), J. Biol. Chem., 274, 30033-30040.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.B39 | cloned from a keratinocyte library, DNA sequence determination and analysis, expression in CHO-K1 cells via infection with Semliki Forest Virus system | Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.B39 | 33000 | - |
about, native and recombinant enzyme, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B39 | polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.B39 | Homo sapiens | Q9Y337 | can be processed to active enzyme from inactive precursor by trypsin | - |
| 3.4.21.B39 | Homo sapiens | Q9Y337 | gene KLK5 or SCTE | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.B39 | glycoprotein | N-glycosylated | Homo sapiens |
| 3.4.21.B39 | proteolytic modification | can be processed to active enzyme from inactive precursor by trypsin | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.B39 | from epidermis | Homo sapiens |
| 3.4.21.B39 | recombinant from CHO-K1 cells | Homo sapiens |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.B39 | proteolytic cleavage of polypeptides | enzyme is a serine protease | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.B39 | brain | - |
Homo sapiens | - |
| 3.4.21.B39 | epidermis | - |
Homo sapiens | - |
| 3.4.21.B39 | epithelium | of plantar skin | Homo sapiens | - |
| 3.4.21.B39 | keratinocyte | - |
Homo sapiens | - |
| 3.4.21.B39 | kidney | - |
Homo sapiens | - |
| 3.4.21.B39 | placenta | - |
Homo sapiens | - |
| 3.4.21.B39 | skin | - |
Homo sapiens | - |
| 3.4.21.B39 | stratum corneum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B39 | polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.B39 | monomer | 1 * 30000-37000, recombinant enzyme, SDS-PAGE | Homo sapiens |
| 3.4.21.B39 | monomer | 1 * 25000-33000, native enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.B39 | strateum-corneum trypsin-like serine protease | - |
Homo sapiens |
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