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Literature summary extracted from

  • Tanimoto, H.; Underwood, L.J.; Shigemasa, K.; Yan Yan, M.S.; Clarke, J.; Parmley, T.H.; O'Brien, T.J.
    The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells (1999), Cancer, 86, 2074-2082.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.117 additional information Homo sapiens enzyme may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells ?
-
 ?
3.4.21.117 polypeptide + H2O Homo sapiens mediates shedding and desquamation of skin cells peptides
-
 ?
3.4.21.117 polypeptide + H2O Homo sapiens catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.117 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.117 cleavage of proteins with aromatic side chains in the P1 position enzyme is a chymotrypsin-like serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.117 additional information no activity in healthy ovary Homo sapiens
-
3.4.21.117 ovarian carcinoma cell different carcinoma cell lines and types, overview Homo sapiens
-
3.4.21.117 ovarian carcinoma cell overexpression of the enzyme Homo sapiens
-
3.4.21.117 skin
-
 Homo sapiens
-
3.4.21.117 stratum corneum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.117 additional information enzyme may contribute to tumor cell growth, tumor spread, and the metastatic potential of ovarian tumor cells Homo sapiens ?
-
 ?
3.4.21.117 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.117 polypeptide + H2O mediates shedding and desquamation of skin cells Homo sapiens peptides
-
 ?
3.4.21.117 polypeptide + H2O catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.117 SCCE
-
 Homo sapiens