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Literature summary extracted from

  • Skytt, A.; Stromqvist, M.; Egelrud, T.
    Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme (1995), Biochem. Biophys. Res. Commun., 211, 586-589.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.117 polypeptide + H2O Homo sapiens involved in desquamation in plantar stratum corneum peptides
-
 ?
3.4.21.117 polypeptide + H2O Homo sapiens catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.117 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.117 cleavage of proteins with aromatic side chains in the P1 position specific for amino acid residues with aromatic side chains in the P1 position Homo sapiens
a
3.4.21.117 cleavage of proteins with aromatic side chains in the P1 position enzyme is a chymotrypsin-like serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.117 epidermis enzyme expression Homo sapiens
-
3.4.21.117 keratinocyte enzyme expression Homo sapiens
-
3.4.21.117 skin
-
 Homo sapiens
-
3.4.21.117 stratum corneum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.117 additional information substrate specificity Homo sapiens ?
-
 ?
3.4.21.117 oxidized bovine insulin B chain + H2O recombinant enzyme Homo sapiens peptides + (Tyr)26 product identification, cleavage sites are: Leu6-cysteic acid7, Tyr16-Leu17, Phe25-Tyr26, Tyr26-Tr27 ?
3.4.21.117 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.117 polypeptide + H2O involved in desquamation in plantar stratum corneum Homo sapiens peptides
-
 ?
3.4.21.117 polypeptide + H2O catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continous sheeding of the cells from the skin surface Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.117 SCCE
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.117 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.117 7.2
-
 assay at Homo sapiens