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Literature summary extracted from

  • Egelrud, T.
    Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation (1993), J. Invest. Dermatol., 101, 200-204.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.117 25000
-
 x * 25000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.117 polypeptide + H2O Homo sapiens involved in desquamation in plantar stratum corneum peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.117 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.117 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.117
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.117 cleavage of proteins with aromatic side chains in the P1 position enzyme is a chymotrypsin-like serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.117 corneocyte plantar Homo sapiens
-
3.4.21.117 skin
-
 Homo sapiens
-
3.4.21.117 stratum corneum hyperplastic Homo sapiens
-
3.4.21.117 stratum corneum plantar Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.117 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.117 D-Ile-Pro-Arg-4-nitroanilide + H2O chromogenic substrate Homo sapiens D-Ile-Pro-Arg + 4-nitroaniline
-
 ?
3.4.21.117 D-Ile-Pro-Arg-4-nitroanilide + H2O i.e. S2288 Homo sapiens D-Ile-Pro-Arg + 4-nitroaniline
-
 ?
3.4.21.117 methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O best substrate Homo sapiens methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline
-
 ?
3.4.21.117 methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O chromogenic substrate Homo sapiens methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline
-
 ?
3.4.21.117 methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O i.e. S2586 Homo sapiens methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline
-
 ?
3.4.21.117 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.117 polypeptide + H2O involved in desquamation in plantar stratum corneum Homo sapiens peptides
-
 ?
3.4.21.117 succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O chromogenic substrate Homo sapiens succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.117 ? x * 25000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.117 SCCE
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.117 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.117 8
-
 assay at Homo sapiens