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Literature summary extracted from
- Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation (1991), Acta Derm. Venereol., 71, 471-474.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.117 | Aprotinin | - |
Homo sapiens |  |
| 3.4.21.117 | chymostatin | - |
Homo sapiens | |
| 3.4.21.117 | additional information | no inhibition by leupeptin | Homo sapiens | |
| 3.4.21.117 | Zn2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 25000 | - |
x * 25000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.117 | polypeptide + H2O | Homo sapiens | involved in desquamation in plantar stratum corneum | peptides | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.117 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.117 | partially | Homo sapiens |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.117 | cleavage of proteins with aromatic side chains in the P1 position | enzyme is a chymotrypsin-like serine protease | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.117 | skin | of the forearm | Homo sapiens | - |
| 3.4.21.117 | stratum corneum | plantar | Homo sapiens | - |
| 3.4.21.117 | stratum corneum | from heels | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.117 | casein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.117 | polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
| 3.4.21.117 | polypeptide + H2O | involved in desquamation in plantar stratum corneum | Homo sapiens | peptides | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.117 | ? | x * 25000, SDS-PAGE | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 8 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 5.5 | 8 | no activity at pH 4.0, highest activity at 8.0 | Homo sapiens |
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Release 2023.1 (January 2023)
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