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Literature summary extracted from

  • Kato, K.; Kishi, T.; Kamachi, T.; Akisada, M.; Oka, T.; Midorikawa, R.; Takio, K.; Dohmae, N.; Bird, P.I.; Sun, J.; Scott, F.; Miyake, Y.; Yamamoto, K.; Machida, A.; Tanaka, T.; Matsumoto, K.; Shibata, M.; Shiosaka, S.
    Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain (2001), J. Biol. Chem., 276, 14562-14571.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.118 overexpression of proneuropsin in Spodoptera frugiperda insect cells via baculovirus infection Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.118 murinoglobulin I 24% inhibition at enzyme-inhibitor ratio of 1:2; formation of a SDS-stable complex; i.e. MUG I Mus musculus
3.4.21.118 serine protease inhibitor-3 formation of a SDS-stable complex, bimolecular kinetics; from pyramidal neurons; slowly and tightly binding inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.118 polypeptide + H2O Mus musculus involvement in neural plasticity peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.118 Mus musculus Q61955
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.118 glycoprotein enzyme contains N-glycosylation sites Mus musculus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.118 recombinant from SF21 insect cells Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.118 brain expressed in the forebrain limbic area of adult brain Mus musculus
-
3.4.21.118 neuron in the hippocampal CA1-CA3 subfields Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.118 polypeptide + H2O
-
 Mus musculus peptides
-
 ?
3.4.21.118 polypeptide + H2O involvement in neural plasticity Mus musculus peptides
-
 ?
3.4.21.118 tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide + H2O
-
 Mus musculus tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.118 NP
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.118 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.118 7.4
-
 assay at Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.118 0.0008
-
 serine protease inhibitor-3 complex formation, pH 7.4, 37°C Mus musculus