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Literature summary extracted from

  • Wang, Y.; Nimec, Z.; Ryan, T.J.; Dias, J.A.; Galivan, J.
    The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells (1993), Biochim. Biophys. Acta, 1164, 227-235.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.9 H35 hepatoma cells Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.9 culture medium of H35 hepatoma cells Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.19.9 5.139
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.9 4-aminobenzoyl-penta-gamma-glutamate + H2O
-
 Rattus norvegicus 4-aminobenzoylglutamate + tetra-gamma-glutamate subsequently degraded to glutamic acid ?
3.4.19.9 methotrexate penta-gamma-glutamate + H2O
-
 Rattus norvegicus methotrexate-gamma-glutamate + tetra-gamma-glutamate subsequently degraded to glutamic acid ?
3.4.19.9 additional information endopeptidase activity Rattus norvegicus ?
-
 ?
3.4.19.9 additional information no hydrolysis of poly-alpha-glutamate Rattus norvegicus ?
-
 ?
3.4.19.9 additional information protein-associated poly-gamma-glutamates are poor substrates Rattus norvegicus ?
-
 ?
3.4.19.9 additional information no hydrolysis of 4-amino-benzoyl-gamma-glutamate Rattus norvegicus ?
-
 ?
3.4.19.9 pteroylpentaglutamate + H2O
-
 Rattus norvegicus ?
-
 ?