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Literature summary extracted from
- Human carboxypeptidase M (1995), Methods Enzymol., 248, 663-675.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.17.12 | - |
Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.17.12 | 0.016 | - |
bradykinin | - |
Homo sapiens |  |
| 3.4.17.12 | 0.046 | - |
Met5-Arg6-enkephalin | - |
Homo sapiens | |
| 3.4.17.12 | 0.063 | - |
Leu5-Arg6-enkephalin | - |
Homo sapiens | |
| 3.4.17.12 | 0.375 | - |
Met5-Lys6-enkephalin | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.17.12 | plasma membrane | - |
Homo sapiens | 5886 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.12 | 62000 | - |
x * 62000, human, SDS-PAGE with or without reduction | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.12 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.17.12 | glycoprotein | carbohydrate content: 23% by weight | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.17.12 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.17.12 | placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.12 | 1.344 | - |
- |
Homo sapiens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.4.17.12 | -20°C, 50% v/v glycerol, stable for at least 1 year | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.12 | benzoyl-Gly-Arg + H2O | - |
Homo sapiens | benzoyl-Gly + Arg | - |
? | |
| 3.4.17.12 | benzoyl-Gly-Lys + H2O | - |
Homo sapiens | benzoyl-Gly + Lys | - |
? | |
| 3.4.17.12 | dynorphin A(1-13) + H2O | i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys | Homo sapiens | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu + Lys | - |
? | |
| 3.4.17.12 | Leu5-Arg6-enkephalin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.17.12 | Met5-Arg6-enkephalin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.17.12 | Met5-Lys6-enkephalin + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.17.12 | ? | x * 62000, human, SDS-PAGE with or without reduction | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.17.12 | 1.77 | - |
Leu5-Arg6-enkephalin | - |
Homo sapiens | |
| 3.4.17.12 | 2.45 | - |
bradykinin | - |
Homo sapiens | |
| 3.4.17.12 | 11.1 | - |
Met5-Lys6-enkephalin | - |
Homo sapiens | |
| 3.4.17.12 | 15.6 | - |
Met5-Arg6-enkephalin | - |
Homo sapiens | |
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