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Literature summary extracted from

  • Lenney, J.F.; George, R.P.; Weiss, A.M.; Kucera, C.M.; Chan, P.W.H.; Rinzler, G.S.
    Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium (1982), Clin. Chim. Acta, 123, 221-231.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.13.20 citrate activates Homo sapiens
3.4.13.20 phosphate activates Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.20 additional information no inhibition by p-hydroxymercuribenzoate, CH2ClCOONa, phenylmethylsulfonyl fluoride Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.20 Cd2+ activates, twice as effective as Mn2+, maximum activity at 0.8-0.9 mM Homo sapiens
3.4.13.20 Mn2+ activates, less effective than Cd2+ Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.13.20 160000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.20 Homo sapiens
-
 little or no activity in children below 10 months in age thereafter, the average concentration increases gradually to reach the adult range at the age 13-15
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.13.20
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.20 blood serum concentration varies greatly between individuals Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.4.13.20 -80°C, stable for several weeks in serum Homo sapiens
3.4.13.20 4°C, stable for a day or two in serum Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.20 carnosine + H2O beta-Ala-His Homo sapiens beta-Ala + His
-
 ?
3.4.13.20 homocarnosine + H2O
-
 Homo sapiens ?
-
 ?
3.4.13.20 additional information no hydrolysis of L-Ala-His, Gly-His or N-acetylhistidine Homo sapiens ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.13.20 50
-
 30 min, pH 7.8, stable, thermostability improved by the presence of 0.25 mM MnCl2, stability is very poor in the presence of 0.25 mM cadmium or calcium Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.13.20 4.7
-
-
 Homo sapiens
3.4.13.20 8 8.5
-
 Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.13.20 7.5 8.2 maximal stability at 50°C Homo sapiens