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Literature summary extracted from
- Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiae (1990), J. Biol. Chem., 265, 19892-19897.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.18 | 1,10-phenanthroline | - |
Saccharomyces cerevisiae |  |
| 3.4.11.18 | EDTA | - |
Saccharomyces cerevisiae | |
| 3.4.11.18 | Hg2+ | HgCl2 | Saccharomyces cerevisiae | |
| 3.4.11.18 | nitrilotriacetic acid | - |
Saccharomyces cerevisiae | |
| 3.4.11.18 | p-hydroxymercuribenzoate | - |
Saccharomyces cerevisiae | |
| 3.4.11.18 | Zn2+ | - |
Saccharomyces cerevisiae | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.18 | 34000 | - |
1 * 34000, SDS-PAGE | Saccharomyces cerevisiae |
| 3.4.11.18 | 36000 | - |
gel filtration | Saccharomyces cerevisiae |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.18 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.11.18 | - |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.18 | additional information | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.18 | Met-Ala-Ser + H2O | also cleaves methionine from other tripeptides with a relatively small and/or uncharged penultimate amino acid residue (Pro, Gly, Val, Thr, or Ser) but not if bulky and/or charged (Arg, His, Leu, Met, or Tyr) | Saccharomyces cerevisiae | Met + Ala-Ser | - |
? | |
| 3.4.11.18 | additional information | no activity with methionine 4-nitroanilide | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.11.18 | monomer | 1 * 34000, SDS-PAGE | Saccharomyces cerevisiae |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.18 | 30 | - |
- |
Saccharomyces cerevisiae |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.18 | 20 | 50 | 20°C: about 60% of activity maximum, 50°C: about 70% of activity maximum | Saccharomyces cerevisiae |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.18 | 7 | - |
- |
Saccharomyces cerevisiae |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.18 | 6 | 7.8 | about 50% of activity maximum at pH 6 and 7.8 | Saccharomyces cerevisiae |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.11.18 | Saccharomyces cerevisiae | - |
- |
8.8 |
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