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Literature summary extracted from

  • Little, G.H.; Starnes, W.L.; Behal, F.J.
    Human liver aminopeptidase (1976), Methods Enzymol., 45, 495-503.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.14 benzylpenicillenic acid
-
 Homo sapiens
3.4.11.14 penicillin
-
 Homo sapiens
3.4.11.14 puromycin
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.14 Co2+ 2.4fold activation, Co2+ binds loosely in a noncompetitive manner Homo sapiens
3.4.11.14 Zinc 8.3 nanoatoms of tightly bound zinc per mg of protein Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.11.14 120000
-
 2 * 120000, SDS-PAGE Homo sapiens
3.4.11.14 223000
-
 sedimentation equilibrium centrifugation Homo sapiens
3.4.11.14 242000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.14 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.11.14 glycoprotein contains 17.5% carbohydrate - 4.3% glucosamine, 4.1% sialic acid, 9% hexoses Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.14
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.14 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.14 Ala-2-naphthylamide + H2O
-
 Homo sapiens Ala + 2-naphthylamine
-
 ?
3.4.11.14 Ala-Ala + H2O 45.4% of the activity with Ala-Trp Homo sapiens Ala + Ala
-
 ?
3.4.11.14 Ala-Asp + H2O 11.4% of the activity with Ala-Trp Homo sapiens Ala + Asp
-
 ?
3.4.11.14 Ala-Glu + H2O 19.0% of the activity with Ala-Trp Homo sapiens Ala + Glu
-
 ?
3.4.11.14 Ala-Gly + H2O 17.8% of the activity with Ala-Trp Homo sapiens Ala + Gly
-
 ?
3.4.11.14 Ala-Leu + H2O 27.1% of the activity with Ala-Trp Homo sapiens Ala + Leu
-
 ?
3.4.11.14 Ala-Phe + H2O 42.8% of the activity with Ala-Trp Homo sapiens Ala + Phe
-
 ?
3.4.11.14 Ala-Ser + H2O 22.5% of the activity with Ala-Trp Homo sapiens Ala + Ser
-
 ?
3.4.11.14 Ala-Trp + H2O
-
 Homo sapiens Ala + Trp
-
 ?
3.4.11.14 Ala-Val + H2O 47.3% of the activity with Ala-Trp Homo sapiens Ala + Val
-
 ?
3.4.11.14 Arg-2-naphthylamide + H2O 28% of the activity with Ala-2-naphthylamide Homo sapiens Arg + 2-naphthylamine
-
 ?
3.4.11.14 Gly-2-naphthylamide + H2O 13.7% of the activity with Ala-2-naphthylamide Homo sapiens Gly + 2-naphthylamine
-
 ?
3.4.11.14 Leu-2-naphthylamide + H2O 36.4% of the activity with Ala-2-naphthylamide Homo sapiens Leu + 2-naphthylamine
-
 ?
3.4.11.14 Leu-Ala + H2O 25.6% of the activity with Ala-Trp Homo sapiens Leu + Ala
-
 ?
3.4.11.14 Leu-Gly + H2O 5.5% of the activity with Ala-Trp Homo sapiens Leu + Gly
-
 ?
3.4.11.14 Leu-Leu + H2O 35.9% of the activity with Ala-Trp Homo sapiens Leu + Leu
-
 ?
3.4.11.14 Lys-2-naphthylamide + H2O 13.4% of the activity with Ala-2-naphthylamide Homo sapiens Lys + 2-naphthylamine
-
 ?
3.4.11.14 Met-2-naphthylamide + H2O 57.5% of the activity with Ala-2-naphthylamide Homo sapiens Met + 2-naphthylamine
-
 ?
3.4.11.14 Phe-2-naphthylamide + H2O 62.8% of the activity with Ala-2-naphthylamide Homo sapiens Phe + 2-naphthylamine
-
 ?
3.4.11.14 Phe-Gly + H2O 19.2% of the activity with Ala-Trp Homo sapiens Phe + Gly
-
 ?
3.4.11.14 Ser-2-naphthylamide + H2O 6.0% of the activity with Ala-2-naphthylamide Homo sapiens Ser + 2-naphthylamine
-
 ?
3.4.11.14 Thr-2-naphthylamide + H2O 5.7% of the activity with Ala-2-naphthylamide Homo sapiens Thr + 2-naphthylamine
-
 ?
3.4.11.14 Trp-2-naphthylamide + H2O 19.2% of the activity with Ala-2-naphthylamide Homo sapiens Trp + 2-naphthylamine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.11.14 dimer 2 * 120000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.14 6.8
-
-
 Homo sapiens