Any feedback?
Literature summary extracted from
- Modification of leukotriene A4 hydrolase/aminopeptidase by sulfhydryl-blocking reagents: Differential effects on dual enzyme activities by methyl-methane thiosulfonate (1999), Arch. Biochem. Biophys., 368, 131-138.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.6 | albumin | - |
Homo sapiens | |
| 3.3.2.6 | Cl- | - |
Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 | pre-treatment of enzyme by methyl-methane thiosulfonate does not protect against suicide inactivation by leukotriene A4 | Homo sapiens | |
| 3.3.2.6 | methyl-methane thiosulfonate | inhibits aminopeptidase activity and NaCl stimulates this inactivation, beta-mercaptoethanol reactivates this inactivation, bestatin protects inactivation, little effect on epoxid hydrolase activity | Homo sapiens | |
| 3.3.2.6 | N-ethylmaleimide | weak | Homo sapiens | |
| 3.3.2.6 | p-hydroxymercuribenzoate | bestatin protects inactivation | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.6 | additional information | - |
additional information | - |
Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.6 | Zinc | zinc protein | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 + H2O | Homo sapiens | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.6 | Homo sapiens | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | the aminopeptidase activity is dependent upon an unmodified cysteine residue, by modifying this cysteine with a small CH3S group it is possible to separate the two enzymatic activities, the aminopeptidase activity and epoxid hydrolase activity, from each other | Homo sapiens | |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | enzyme contains two partly overlapping active sites which influence each other | Homo sapiens | |
| 3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.3.2.6 | lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.6 | leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
| 3.3.2.6 | leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Homo sapiens | leukotriene B4 | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.6 | additional information | - |
additional information | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
