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Literature summary extracted from

  • Jendraschak, E.; Kaminski, W.E.; Kiefl, R.; von Schacky, C.
    The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms (1996), Biochem. J., 314, 733-737.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.6 identification of two isoforms of the mRNA, short and long, by using a sequential reverse transcriptase (RT)-PCR mapping approach, both enzyme mRNAs are expressed in blood cells, endothelial cells, smooth muscle cells, fibroblasts and tumor cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.6 cytosol
-
 Homo sapiens 5829
-
3.3.2.6 additional information the short- and long-form mRNA expression levels of selected number of cell types is analysed by quantitative RT-PCR Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zinc the sequence that codes for the zinc-ion-binding motif is identical in the short-from and long-form enzyme mRNAs Homo sapiens
3.3.2.6 Zinc zinc protein Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.6 59000
-
 novel short-form mRNA Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens P09960
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.3.2.6 Homo sapiens short-form enzyme
-
 5.24
3.3.2.6 Homo sapiens long-form enzyme
-
 5.76