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Literature summary extracted from

  • Ohishi, N.; Izumi, T.; Minami, M.; Kitamura, S.; Seyama, Y.; Ohkawa, S.; Terao, S.; Yotsumoto, H.; Takaku, F.; Shimizu, T.
    Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers (1987), J. Biol. Chem., 262, 10200-10205.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 14,15-Leukotriene A4
-
Homo sapiens
3.3.2.6 HgCl2
-
Homo sapiens
3.3.2.6 leukotriene A4 suicide inactivation Homo sapiens
3.3.2.6 leukotriene A4 methyl ester
-
Homo sapiens
3.3.2.6 N-ethylmaleimide
-
Homo sapiens
3.3.2.6 PCMB
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.3.2.6 additional information
-
additional information
-
Homo sapiens
3.3.2.6 0.013 0.014 leukotriene A4 pH 7.8, 37°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.6 49000 50000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.6
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 lung
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.3.2.6 2 3
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?
3.3.2.6 leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?

Subunits

EC Number Subunits Comment Organism
3.3.2.6 monomer 1 * 68000-70000, SDS-PAGE Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.3.2.6 0.0005
-
HgCl2 pH 7.8, 37°C Homo sapiens
3.3.2.6 0.0007
-
PCMB pH 7.8, 37°C Homo sapiens
3.3.2.6 3
-
NEM pH 7.8, 37°C Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.3.2.6 Homo sapiens chromatofocusing
-
5.1