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Literature summary extracted from

  • Haeggström, J.; Radmark, O.; Fitzpatrick, F.A.
    Leukotriene A4-hydrolase activity in guinea pig and human liver (1985), Biochim. Biophys. Acta, 835, 378-384.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.6 medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus
3.3.2.6 medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Cavia porcellus
-
-
-
3.3.2.6 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.3.2.6 additional information enzyme is susceptible to proteolytic digestion Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 kidney
-
 Cavia porcellus
-
3.3.2.6 kidney
-
 Homo sapiens
-
3.3.2.6 liver
-
 Cavia porcellus
-
3.3.2.6 liver
-
 Homo sapiens
-
3.3.2.6 lung
-
 Cavia porcellus
-
3.3.2.6 lung
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.3.2.6 -20°C, 95% of activity after 12 days Cavia porcellus
3.3.2.6 4°C, 50% loss of activity after 12 days Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Cavia porcellus leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.3.2.6 56
-
 1 h, complete loss of activity Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.6 7 8.5
-
 Cavia porcellus