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Literature summary extracted from

  • Kuznetsov, S.V.; Sidorkina, O.M.; Jurado, J.; Bazin, M.; Tauc, P.; Brochon, J.C.; Laval, J.; Santus, R.
    Effect of single mutations on the structural dynamics of a DNA repair enzyme, the Escherichia coli formamidopyrimidine-DNA glycosylase. A fluorescence study using tryptophan residues as reporter groups (1998), Eur. J. Biochem., 253, 413-420.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.2.2.23 K57G study of the effect of the mutation on the structure dynamics, mutant with decreased 8-hydroxyguanine-DNA glycosylase activity Escherichia coli
3.2.2.23 P2E study of the effect of the mutation on the structure dynamics, mutation causes complete loss of DNA glycosylase/beta-lyase activity and induces a conformational change leading to a more rigid globular structure than wild-type, K57G and P2G Fpg Escherichia coli
3.2.2.23 P2G study of the effect of the mutation on the structure dynamics, mutant with complete loss of beta-lyase and partial loss of DNA glycosylase activity Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.2.23 Zn2+ possesses a zinc finger Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.23 DNA + H2O Escherichia coli involved in the repair of oxidized purines generated in the genome by endogenous or exogenous oxidative stress ?
-
?
3.2.2.23 DNA + H2O Escherichia coli BH20 involved in the repair of oxidized purines generated in the genome by endogenous or exogenous oxidative stress ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.23 Escherichia coli
-
containing pFPG220
-
3.2.2.23 Escherichia coli BH20
-
containing pFPG220
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.23 wild-type and K57G, P2G, P2E mutant Fpg Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.23 DNA + H2O removes oxidized purines from oxidatively damaged DNA Escherichia coli ?
-
?
3.2.2.23 DNA + H2O enzyme has N-glycosylase and apurinic/apyrimidinic lyase activity Escherichia coli ?
-
?
3.2.2.23 DNA + H2O involved in the repair of oxidized purines generated in the genome by endogenous or exogenous oxidative stress Escherichia coli ?
-
?
3.2.2.23 DNA + H2O removes oxidized purines from oxidatively damaged DNA Escherichia coli BH20 ?
-
?
3.2.2.23 DNA + H2O enzyme has N-glycosylase and apurinic/apyrimidinic lyase activity Escherichia coli BH20 ?
-
?
3.2.2.23 DNA + H2O involved in the repair of oxidized purines generated in the genome by endogenous or exogenous oxidative stress Escherichia coli BH20 ?
-
?
3.2.2.23 DNA containing 8-hydroxyguanine residues + H2O
-
Escherichia coli 8-hydroxyguanine + DNA
-
?
3.2.2.23 DNA containing 8-hydroxyguanine residues + H2O
-
Escherichia coli BH20 8-hydroxyguanine + DNA
-
?
3.2.2.23 DNA containing ring-opened N7-methylguanine residues + H2O
-
Escherichia coli 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine + DNA
-
?
3.2.2.23 DNA containing ring-opened N7-methylguanine residues + H2O
-
Escherichia coli BH20 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine + DNA
-
?