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Literature summary extracted from

  • Igdoura, S.A.; Herscovics, A.; Lal, A.; Moremen, K.W.; Morales, C.R.; Hermo, L.
    alpha-Mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymis (1999), Eur. J. Cell Biol., 78, 441-452.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.114 Golgi membrane type II transmembrane enzyme, subcompartmental localization, mainly over medial saccules of the Golgi stack Rattus norvegicus 139
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.114 Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O Rattus norvegicus involved in N-glycan maturation, acts after GlcNAc transferase I to remove 2 mannose residues to form GlcNAc(Man)3(GlcNAc)2 prior to extension into complex N-glycans Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.114 Rattus norvegicus
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 male sprague-dawley rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.114 epididymis clear cells in all epdididymal regions, not in principal cells Rattus norvegicus
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3.2.1.114 Leydig cell in the Golgi apparatus Rattus norvegicus
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3.2.1.114 Sertoli cell in the Golgi apparatus Rattus norvegicus
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3.2.1.114 testis in the Golgi apparatus of Sertoli and Leydig cells Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.114 Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O acts after GlcNAc transferase I to remove the alpha-1,3- and alpha-1,6-linked mannose residue Rattus norvegicus Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
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 ?
3.2.1.114 Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 H2O involved in N-glycan maturation, acts after GlcNAc transferase I to remove 2 mannose residues to form GlcNAc(Man)3(GlcNAc)2 prior to extension into complex N-glycans Rattus norvegicus Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + 2 alpha-D-mannose
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 ?