Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hill, C.M.; Li, W.S.; Cheng, T.C.; DeFrank, J.J.; Raushel, F.M.
    Stereochemical specificity of organophosphorus acid anhydrolase toward p-nitrophenyl analogs of soman and sarin (2001), Bioorg. Chem., 29, 27-35.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.8.2 degradation enzyme catalyse the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds, including pesticides and chemical nerve agents Alteromonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.8.2 additional information
-
 additional information
-
 Alteromonas sp.

Organism

EC Number Organism UniProt Comment Textmining
3.1.8.2 Alteromonas sp.
-
 JD6.5, halophilic bacterium
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.8.2 diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride enzyme exhibits stereoselectivity toward the chiral phosphorus center of the p-nitrophenyl analogs of sarin and soman Alteromonas sp.
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.8.2 O-cyclohexylmethylphosphonofluoridate + H2O i.e. GF Alteromonas sp. ?
-
 ?
3.1.8.2 paraoxon + H2O i.e. diethyl-4-nitrophenyl phosphate, poor substrate Alteromonas sp. diethylphosphate + 4-nitrophenol
-
 ?
3.1.8.2 sarin + H2O substrates are also p-nitrophenyl analogs of sarin, the enzyme exhibits a stereoselective preference for the R-P-enantiomers of sarin Alteromonas sp. ?
-
 ?
3.1.8.2 soman + H2O substrates are also p-nitrophenyl analogs of soman, the enzyme exhibits a stereoselective preference for the R-P-enantiomers of soman Alteromonas sp. ?
-
 ?