BRENDA - Enzyme Database

A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma

Low, M.G.; Prasad, A.R.S.; Proc. Natl. Acad. Sci. USA 85, 980-984 (1988)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.50
n-butanol
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
Homo sapiens
3.1.4.50
n-butanol
-
Oryctolagus cuniculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.50
1,10-phenanthroline
more effective than EGTA
Homo sapiens
3.1.4.50
1,10-phenanthroline
more effective than EGTA
Oryctolagus cuniculus
3.1.4.50
1,10-phenanthroline
more effective than EGTA
Rattus norvegicus
3.1.4.50
1,10-phenanthroline
-
Bos taurus
3.1.4.50
EGTA
Ca2+ partially reverses
Homo sapiens
3.1.4.50
EGTA
Ca2+ partially reverses
Oryctolagus cuniculus
3.1.4.50
EGTA
Ca2+ partially reverses
Rattus norvegicus
3.1.4.50
EGTA
-
Bos taurus
3.1.4.50
additional information
no inhibition by leupeptin
Homo sapiens
3.1.4.50
additional information
no inhibition by leupeptin; no inhibition by PMSF
Oryctolagus cuniculus
3.1.4.50
additional information
no inhibition by leupeptin; no inhibition by PMSF
Rattus norvegicus
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Homo sapiens
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Oryctolagus cuniculus
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.50
Ca2+
activation
Oryctolagus cuniculus
3.1.4.50
Ca2+
activation
Rattus norvegicus
3.1.4.50
Ca2+
activation
Bos taurus
3.1.4.50
Ca2+
activation
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Gallus gallus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Gallus gallus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Homo sapiens
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Rattus norvegicus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Bos taurus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Bos taurus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Oryctolagus cuniculus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Oryctolagus cuniculus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Canis lupus familiaris
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Canis lupus familiaris
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Equus caballus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Equus caballus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.50
Bos taurus
-
fetus
-
3.1.4.50
Canis lupus familiaris
-
-
-
3.1.4.50
Equus caballus
-
-
-
3.1.4.50
Gallus gallus
-
-
-
3.1.4.50
Homo sapiens
-
-
-
3.1.4.50
Oryctolagus cuniculus
-
-
-
3.1.4.50
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.4.50
partial
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.50
placenta
-
Homo sapiens
-
3.1.4.50
plasma
heparinized
Homo sapiens
-
3.1.4.50
plasma
heparinized
Oryctolagus cuniculus
-
3.1.4.50
plasma
heparinized
Rattus norvegicus
-
3.1.4.50
plasma
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.50
5'-nucleotidase + H2O
isolated from rat liver
646473
Rattus norvegicus
?
-
-
-
?
3.1.4.50
5'-nucleotidase + H2O
isolated from rat liver
646473
Oryctolagus cuniculus
?
-
-
-
?
3.1.4.50
alkaline phosphatase + H2O
isolated from human placenta
646473
Rattus norvegicus
?
-
-
-
?
3.1.4.50
alkaline phosphatase + H2O
isolated from human placenta
646473
Oryctolagus cuniculus
?
-
-
-
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Oryctolagus cuniculus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
3.1.4.50
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Rattus norvegicus
?
-
-
-
-
3.1.4.50
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Oryctolagus cuniculus
?
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.50
n-butanol
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
Homo sapiens
3.1.4.50
n-butanol
-
Oryctolagus cuniculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.50
1,10-phenanthroline
more effective than EGTA
Homo sapiens
3.1.4.50
1,10-phenanthroline
more effective than EGTA
Oryctolagus cuniculus
3.1.4.50
1,10-phenanthroline
more effective than EGTA
Rattus norvegicus
3.1.4.50
1,10-phenanthroline
-
Bos taurus
3.1.4.50
EGTA
Ca2+ partially reverses
Homo sapiens
3.1.4.50
EGTA
Ca2+ partially reverses
Oryctolagus cuniculus
3.1.4.50
EGTA
Ca2+ partially reverses
Rattus norvegicus
3.1.4.50
EGTA
-
Bos taurus
3.1.4.50
additional information
no inhibition by leupeptin
Homo sapiens
3.1.4.50
additional information
no inhibition by leupeptin; no inhibition by PMSF
Oryctolagus cuniculus
3.1.4.50
additional information
no inhibition by leupeptin; no inhibition by PMSF
Rattus norvegicus
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Homo sapiens
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Oryctolagus cuniculus
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.50
Ca2+
activation
Oryctolagus cuniculus
3.1.4.50
Ca2+
activation
Rattus norvegicus
3.1.4.50
Ca2+
activation
Bos taurus
3.1.4.50
Ca2+
activation
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Gallus gallus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Gallus gallus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Homo sapiens
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Rattus norvegicus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Bos taurus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Bos taurus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Oryctolagus cuniculus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Oryctolagus cuniculus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Canis lupus familiaris
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Canis lupus familiaris
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Equus caballus
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Equus caballus
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.50
partial
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.50
placenta
-
Homo sapiens
-
3.1.4.50
plasma
heparinized
Homo sapiens
-
3.1.4.50
plasma
heparinized
Oryctolagus cuniculus
-
3.1.4.50
plasma
heparinized
Rattus norvegicus
-
3.1.4.50
plasma
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.50
5'-nucleotidase + H2O
isolated from rat liver
646473
Rattus norvegicus
?
-
-
-
?
3.1.4.50
5'-nucleotidase + H2O
isolated from rat liver
646473
Oryctolagus cuniculus
?
-
-
-
?
3.1.4.50
alkaline phosphatase + H2O
isolated from human placenta
646473
Rattus norvegicus
?
-
-
-
?
3.1.4.50
alkaline phosphatase + H2O
isolated from human placenta
646473
Oryctolagus cuniculus
?
-
-
-
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Oryctolagus cuniculus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Gallus gallus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Gallus gallus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Bos taurus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Bos taurus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Canis lupus familiaris
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Canis lupus familiaris
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Equus caballus
phosphatidic acid + variant-surface-glycoprotein inositol
-
646473
Equus caballus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Rattus norvegicus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Rattus norvegicus
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646473
Oryctolagus cuniculus
phosphatidic acid + variant-surface-glycoprotein inositol
dimyristoylphosphatidic acid
646473
Oryctolagus cuniculus
?
3.1.4.50
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Rattus norvegicus
?
-
-
-
-
3.1.4.50
additional information
little or no activity towards phosphatidylinositol or phosphatidylcholine
646473
Oryctolagus cuniculus
?
-
-
-
-