BRENDA - Enzyme Database

Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases

Malik, A.S.; Low, M.G.; Biochem. J. 240, 519-527 (1986)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.50
n-butanol
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.50
Chloropromazine
partial
Homo sapiens
3.1.4.50
EGTA
Ca2+ partially reverses
Homo sapiens
3.1.4.50
additional information
no inhibition by leupeptin; no inhibition by trifluoperazine
Homo sapiens
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.50
membrane
-
Homo sapiens
16020
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.50
Ca2+
requirement
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Homo sapiens
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Homo sapiens
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.50
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.50
placenta
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646472
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646472
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
cleaves phosphodiester linkage to diacylglycerol
646472
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646472
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646472
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646472
Homo sapiens
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.50
n-butanol
activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.50
Chloropromazine
partial
Homo sapiens
3.1.4.50
EGTA
Ca2+ partially reverses
Homo sapiens
3.1.4.50
additional information
no inhibition by leupeptin; no inhibition by trifluoperazine
Homo sapiens
3.1.4.50
p-Hydroxymercuriphenylsulfonic acid
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.4.50
membrane
-
Homo sapiens
16020
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.50
Ca2+
requirement
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
Homo sapiens
-
phosphatidic acid + variant-surface-glycoprotein inositol
-
Homo sapiens
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.50
placenta
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
-
646472
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646472
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
cleaves phosphodiester linkage to diacylglycerol
646472
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646472
Homo sapiens
?
3.1.4.50
membrane form of variant-surface-glycoprotein + H2O
phospholipase D-type hydrolysis
646472
Homo sapiens
phosphatidic acid + variant-surface-glycoprotein inositol
-
646472
Homo sapiens
?