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Literature summary extracted from

  • Chi, H.; Tiller, G.E.; Dasouki, M.J.; Romano, P.R.; Wang, J.; O'Keefe, R.J.; Puzas, J.E.; Rosier, R.N.; Reynolds, P.R.
    Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19 (1999), Genomics, 56, 324-336.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.62 located on chromosome 10q23, genomic organization Homo sapiens
3.1.3.62 sequenced and expressed in Escherichia coli JM109, located on chromosome 19, genomic organization Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.62 additional information mutant with active site histidine altered to alanine has abolished enzyme activity Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.62 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.1.3.62 endoplasmic reticulum
-
 Mus musculus 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.62 54500
-
 x * 54500, inclusive the putative signal sequence, amino acid sequence analysis Mus musculus
3.1.3.62 55100
-
 x * 55100, inclusive the putative signal sequence, amino acid sequence analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.62 Homo sapiens Q9UNW1 (HSA)MINPP1
-
3.1.3.62 Mus musculus Q9Z2L6 (MMU)Minpp1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.62 recombinant (MMU)Minpp1 fusion protein expressed in Escherichia coli JM109 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.62 brain mRNA expression Mus musculus
-
3.1.3.62 chondrocyte fetal growth plate cartilage, mRNA expression Homo sapiens
-
3.1.3.62 heart mRNA expression Mus musculus
-
3.1.3.62 HeLa cell mRNA expression Homo sapiens
-
3.1.3.62 intestine mRNA expression Mus musculus
-
3.1.3.62 kidney highest mRNA expression Mus musculus
-
3.1.3.62 liver mRNA expression Mus musculus
-
3.1.3.62 lung mRNA expression Mus musculus
-
3.1.3.62 additional information tissue distribution of (MMU)Minpp1 mRNA Mus musculus
-
3.1.3.62 skin mRNA expression Mus musculus
-
3.1.3.62 spleen mRNA expression Mus musculus
-
3.1.3.62 testis mRNA expression Mus musculus
-
3.1.3.62 thymus mRNA expression Mus musculus
-

Storage Stability

EC Number Storage Stability Organism
3.1.3.62 0°C, 10 mM Tris-HCl, pH 7.4, 100 mM KCl, 1 mM dithiothreitol, up to 1 month, stable Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.62 4-nitrophenyl phosphate + H2O
-
 Mus musculus 4-nitrophenol + phosphate
-
 ?
3.1.3.62 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Mus musculus D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.62 ? x * 54500, inclusive the putative signal sequence, amino acid sequence analysis Mus musculus
3.1.3.62 ? x * 55100, inclusive the putative signal sequence, amino acid sequence analysis Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.62 (HSA)MINPP1
-
 Homo sapiens
3.1.3.62 (MMU)Minpp1
-
 Mus musculus
3.1.3.62 More distinct group within the histidine phosphatase family Homo sapiens
3.1.3.62 More distinct group within the histidine phosphatase family Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.62 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.62 7.4
-
 assay at Mus musculus