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Literature summary extracted from

  • Mochizuki, Y.; Takenawa, T.
    Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles (1999), J. Biol. Chem., 274, 36790-36795.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.56 expressed in COS-7 cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.56 DELTA1-119 no significant influence on localization of enzyme Rattus norvegicus
3.1.3.56 DELTA1-311 no significant influence on localization of enzyme Rattus norvegicus
3.1.3.56 DELTA1-433 enzyme mainly in cytoplasm Rattus norvegicus
3.1.3.56 DELTA725-1001 enzyme exclusively cytoplasmic Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 membrane ruffling membranes Rattus norvegicus 16020
-
3.1.3.56 membrane two isoforms postulated one of which is membrane associated Rattus norvegicus 16020
-
3.1.3.56 soluble two isoforms postulated one of which is soluble Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.56 107000
-
 calculated molecular mass, found to be slightly larger in SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O Rattus norvegicus regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels phosphatidylinositol 4-phosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Rattus norvegicus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.56 phosphoprotein cytoplasmic enzyme highly phosphorylated Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain PIPP enzyme Rattus norvegicus
-
3.1.3.56 heart PIPP enzyme Rattus norvegicus
-
3.1.3.56 kidney PIPP enzyme Rattus norvegicus
-
3.1.3.56 liver isoform of PIPP enzyme Rattus norvegicus
-
3.1.3.56 lung PIPP enzyme Rattus norvegicus
-
3.1.3.56 additional information PIPP enzyme not expressed in spleen, thymus, skeletal muscle, testis and skin Rattus norvegicus
-
3.1.3.56 small intestine PIPP enzyme Rattus norvegicus
-
3.1.3.56 stomach PIPP enzyme Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
-
 Rattus norvegicus phosphatidylinositol 4-phosphate + phosphate
-
 ?
3.1.3.56 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels Rattus norvegicus phosphatidylinositol 4-phosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.56 proline-rich inositol polyphosphate 5-phosphatase PIPP Rattus norvegicus