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Literature summary extracted from

  • De Smedt, F.; Boom, A.; Pesesse, X.; Schiffmann, S.N.; Erneux, C.
    Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation (1996), J. Biol. Chem., 271, 10419-10424.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.56 expressed in COS-7 and CHO cells and Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.56 C409S predominantly soluble Homo sapiens
3.1.3.56 DELTA407-411 predominantly soluble Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 membrane major part of activity is membrane bound Homo sapiens 16020
-
3.1.3.56 membrane major part of activity is membrane bound Rattus norvegicus 16020
-
3.1.3.56 soluble
-
 Homo sapiens
-
-
3.1.3.56 soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.56 43000
-
 SDS-PAGE, type I enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Rattus norvegicus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Homo sapiens
-
-
-
3.1.3.56 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.56 side-chain modification farnesylation at Cys-409 Homo sapiens
3.1.3.56 side-chain modification farnesylation Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.56 recombinant enzymes from Escherichia coli using His-tag Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?